2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. Inhibin alpha Antibody (YA1232)

Inhibin alpha Antibody (YA1232)

Cat. No.: HY-P81487
User Guide for Antibodies Technical Support

Inhibin alpha Antibody (YA1232) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Inhibin alpha.

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사이즈 가격 재고 수량
20 μL 견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL 견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL 견적 받기 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   견적 받기  
Synthetic products have potential research and development risk.
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 제품 설명

제품 설명

Inhibin alpha Antibody (YA1232) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Inhibin alpha.
Host

Rabbit
Clonality

Recombinant, Monoclonal
분자량
Predicted band size: 40 kDa;
Observed band size: 40 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human Inhibin alpha
Application &
Dilution Ratio
Application Dilution Ratio
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:100-1:200
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.57.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
선적

Shipping with blue ice.
Background
Function：Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Inhibin A is a dimer of alpha/INHA and beta-A/INHBA that functions as a feedback regulator in the hypothalamic-pituitary-gonadal (HPG) axis. Inhibits the secretion of FSH from the anterior pituitary gland by acting on pituitary gonadotrope cells. Antagonizes activin A by binding to the proteoglycan, betaglycan, and forming a stable complex with and, thereby, sequestering type II activin receptors while excluding type I receptor; Inhibin B is a dimer of alpha and beta-B that plays a crucial role in the regulation of the reproductive system by inhibiting the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Thereby, maintains reproductive homeostasis in both males and females. Acts as a more potent suppressor of FSH release than inhibin A (By similarity). Functions as competitive receptor antagonist binding activin type II receptors with high affinity in the presence of the TGF-beta type III coreceptor/TGFBR3L (PubMed:34910520)
Subcellular Localization：Secreted
Expression：
Tissue_specificity:Initially found in the ovaries (granulosa cells) and testes (Stewardess cells) , it is widely distributed in various tissues, including the brain and placenta. In normal adrenal cortex, its expression is limited to the zona reticularis and the innermost zona fasciculata; in a proliferative state, its expression extends centripetally to the zona fasciculata. It is also found in adrenal cortical tumors. It is also expressed in the prostatic epithelium of benign prostatic hyperplasia, basal cell hyperplasia areas, and non-malignant areas of high-grade prostate cancer. In men, only circulating inhibin B is detected, while in women, circulating inhibin A and B are detected.
Subunit：Dimeric, linked by one or more disulfide bonds. Activin B is a dimer of alpha and beta-B. Inhibin A is a dimer of alpha and beta-A (PubMed:11786387). Inhibin B is a dimer of alpha and beta-B (PubMed:11786387). Interacts with TGFBR3L; this interaction regulates female fertility
Database

Entrez Gene: 3623 Human

SwissProt: P05111 Human

OMIM: 147380 Human

Research Field

Signal Transduction
Synonyms
Inhibin alpha chain
각종 서류
User Guide for Antibodies (1077 KB)

Inhibin alpha Antibody (YA1232) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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상품명:
Inhibin alpha Antibody (YA1232)
Cat. No.:
HY-P81487
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