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Cat. No.: HY-190532

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InhA-IN-12

InhA-IN-12 is a mycobacterial inhibitor. InhA-IN-12 exhibits concentration- and time-dependent bactericidal activity against Mycobacterium tuberculosis and shows intracellular antimycobacterial activity in infected macrophages. InhA-IN-12 interferes with the InhA-related mycolic acid biosynthesis pathway, and is predicted to fit into the active site and form a stable InhA-ligand complex. InhA-IN-12 has low cytotoxicity toward mammalian cells and high selectivity for mycobacteria. InhA-IN-12 can be used in tuberculosis-related research.

For research use only. We do not sell to patients.

CAS No.: 855988-62-4
Formula: C₂₁H₁₄ClN₃
Molecular Weight:343.81

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

InhA-IN-12 Chemical Structure

CAS No.: 855988-62-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

Bacterial InfectionInnate ImmunityOthers

Bacterial Infection

InhA-IN-12 (Compound 14b) inhibits Mycobacterium tuberculosis mc² 6230 with an MIC of 0.5 μg/mL^[1].
InhA-IN-12 shows significantly reduced activity against isoniazid-resistant Mycobacterium tuberculosis mc² 8243, with an MIC >32 μg/mL^[1].
InhA-IN-12 has a CC₅₀ >100 μg/mL in HepG2 cells, with a selectivity index >200 against Mycobacterium tuberculosis mc² 6230^[1].
InhA-IN-12 (1-8× MIC; 5-10 days) exhibits concentration- and time-dependent bactericidal activity against Mycobacterium tuberculosis mc² 6230^[1].

Bacterial Infection

Innate Immunity

InhA-IN-12 (1-8× MIC) reduces the intracellular Mycobacterium tuberculosis H37Ra burden in THP-1 macrophages in a concentration-dependent manner^[1].

Others

InhA-IN-12 is predicted by docking and molecular dynamics simulations to accommodate the active site and form a stable InhA-ligand complex.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

M. tuberculosis mc2 6230
Concentration:

1, 4 and 8× MIC
Incubation Time:

5 day and 10 day
Result:

Exhibited bactericidal activity against Mycobacterium tuberculosis mc² 6230 in a concentration- and time-dependent manner; treatment at 8× MIC for 5 days resulted in a reduction of approximately 3 log₁₀ CFU, while treatment at 4-8× MIC for 10 days brought the colony count close to the limit of detection.

Related Protocols :

Chemical Information

CAS No. 855988-62-4
Molecular Weight 343.81
Formula C₂₁H₁₄ClN₃
SMILES

ClC1=CC=C(CN2C3=CC=CC=C3C4=C2N=C(C=CC=C5)C5=N4)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bellapukonda SM, et al. Exploration of novel indolo[2,3-b]quinoxaline hybrids as InhA inhibitors: A multi-disciplinary approach involving synthesis, antimycobacterial evaluation and computational studies. Eur J Med Chem. 2026 Sep 17;320:119317.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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