Pyridomycin-4-F
Pyridomycin-4-F, Pyridomycin (HY-111402) derivative, is an antimycobacterial agent targeting fatty acid synthesis enzyme InhA (enoyl ACP reductase). Pyridomycin-4-F binds to the pyridomycin binding pocket of InhA, forms hydrogen bond interactions with Lys-165. Pyridomycin-4-F can be used for the research of tuberculosis.
For research use only. We do not sell to patients.
- Formula: C27H31FN4O8
- Molecular Weight:558.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Pyridomycin-4-F (Compound 13) potently inhibits wild-type Mycobacterium tuberculosis H37Rv with a MIC95 of 0.07 μg/mL, and its activity is reduced by InhAM161L mutation and InhA overexpression, confirming on-target InhA inhibition[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Cmax | Tmax | T1/2 | AUC0-∞ |
|---|---|---|---|---|---|---|
| Mice[1] | 10 mg/kg | i.p. | 1.16 μg/mL | 15 min | 4.8 min | 0.33 μg·h/mL |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (female, intratracheal infection with luminescent Mycobacterium tuberculosis H37Rv-lux)[1]
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Dosage:25 mg/kg (alone); 25 mg/kg + 50 mg/kg ABT (pre-treatment)
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Administration:i.p.; twice daily; 6 days; p.o. (ABT, twice daily; 6 days, 1 hour pre-treatment)
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Result:Failed to reduce lung bacterial load, with results equivalent to vehicle control.
Chemical Information
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Molecular Weight 558.56
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Formula C27H31FN4O8
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SMILES
O=C(N[C@H](C(N[C@@H](CC1=CC=CN=C1)[C@@H](O)[C@H]2C)=O)[C@@H](C)OC(/C(OC2=O)=C(CC)\C)=O)C3=NC=CC(F)=C3O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pyridomycin-4-F Related Classifications
HY-181779 Related Classifications
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