2. Anti-infection
  3. Bacterial
  4. Pyridomycin-4-F

Pyridomycin-4-F, Pyridomycin (HY-111402) derivative, is an antimycobacterial agent targeting fatty acid synthesis enzyme InhA (enoyl ACP reductase). Pyridomycin-4-F binds to the pyridomycin binding pocket of InhA, forms hydrogen bond interactions with Lys-165. Pyridomycin-4-F can be used for the research of tuberculosis.

For research use only. We do not sell to patients.

Pyridomycin-4-F

Pyridomycin-4-F Chemical Structure

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Pyridomycin-4-F Related Antibodies

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Description

Pyridomycin-4-F, Pyridomycin (HY-111402) derivative, is an antimycobacterial agent targeting fatty acid synthesis enzyme InhA (enoyl ACP reductase). Pyridomycin-4-F binds to the pyridomycin binding pocket of InhA, forms hydrogen bond interactions with Lys-165. Pyridomycin-4-F can be used for the research of tuberculosis[1].

In Vitro

Pyridomycin-4-F (Compound 13) potently inhibits wild-type Mycobacterium tuberculosis H37Rv with a MIC95 of 0.07 μg/mL, and its activity is reduced by InhAM161L mutation and InhA overexpression, confirming on-target InhA inhibition[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pyridomycin-4-F Related Antibodies
Parmacokinetics
Species Dose Route Cmax Tmax T1/2 AUC0-∞
Mice[1] 10 mg/kg i.p. 1.16 μg/mL 15 min 4.8 min 0.33 μg·h/mL
In Vivo

Pyridomycin-4-F (Compound 13) (25 mg/kg; i.p.; twice daily; 6 days), either alone or with 50 mg/kg ABT (HY-103389) (p.o.; twice daily; 6 days, 1 hour pre-treatment), fails to reduce lung bacterial load in BALB/c mice infected with luminescent Mycobacterium tuberculosis H37Rv-lux[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (female, intratracheal infection with luminescent Mycobacterium tuberculosis H37Rv-lux)[1]
Dosage: 25 mg/kg (alone); 25 mg/kg + 50 mg/kg ABT (pre-treatment)
Administration: i.p.; twice daily; 6 days; p.o. (ABT, twice daily; 6 days, 1 hour pre-treatment)
Result: Failed to reduce lung bacterial load, with results equivalent to vehicle control.
Molecular Weight

558.56

Formula

C27H31FN4O8
SMILES

O=C(N[C@H](C(N[C@@H](CC1=CC=CN=C1)[C@@H](O)[C@H]2C)=O)[C@@H](C)OC(/C(OC2=O)=C(CC)\C)=O)C3=NC=CC(F)=C3O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Pyridomycin-4-F Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pyridomycin-4-FBacterialMycobacterium tuberculosis H37Rv-luxMycobacterium tuberculosis H37Rvmouse liver microsomesInhAInhA(M161L) mutationmurine pulmonary tuberculosis modelcytochrome P450BALB/c miceLys-165CD-1 miceInhibitorinhibitorinhibit

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