2. Anti-infection
  3. Bacterial
  4. Antimycobacterial agent-16

Antimycobacterial agent-16 is a pyrazinamide derivative and antimycobacterial agent with a selectivity index >25 against HepG2 cells.Antimycobacterial agent-16 does not undergo hydrolysis by mycobacterial pyrazinamidase.Antimycobacterial agent-16 exerts activity against Mycobacterium tuberculosis H37Rv, multidrug-resistant Mycobacterium tuberculosis strains, and Mycobacterium kansasii.Antimycobacterial agent-16 shows no inhibitory activity against mycobacterial enoyl-ACP reductase (InhA).Antimycobacterial agent-16 has low cytotoxicity against HepG2 cells.Antimycobacterial agent-16 can be used for the research of tuberculosis.

For research use only. We do not sell to patients.

Antimycobacterial agent-16

Antimycobacterial agent-16 Chemical Structure

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Antimycobacterial agent-16 Related Antibodies

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Description

Antimycobacterial agent-16 is a pyrazinamide derivative and antimycobacterial agent with a selectivity index >25 against HepG2 cells.Antimycobacterial agent-16 does not undergo hydrolysis by mycobacterial pyrazinamidase.Antimycobacterial agent-16 exerts activity against Mycobacterium tuberculosis H37Rv, multidrug-resistant Mycobacterium tuberculosis strains, and Mycobacterium kansasii.Antimycobacterial agent-16 shows no inhibitory activity against mycobacterial enoyl-ACP reductase (InhA).Antimycobacterial agent-16 has low cytotoxicity against HepG2 cells.Antimycobacterial agent-16 can be used for the research of tuberculosis[1].

In Vitro

Antimycobacterial agent-16 (Compound 23) potently inhibits the growth of Mycobacterium tuberculosis H37Rv and Mycobacterium kansasii, with MIC values of 3.13 μg/mL and 12.5 μg/mL, respectively[1].
Antimycobacterial agent-16 exhibits low cytotoxicity against HepG2 cells (IC50 = 238.3 μM), with a favorable selectivity index of 25.7 against Mycobacterium tuberculosis H37Rv.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antimycobacterial agent-16 Related Antibodies
Molecular Weight

337.34

Formula

C17H18F3N3O
SMILES

O=C(C1=NC=C(CCCCC)N=C1)NC2=CC=CC(C(F)(F)F)=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antimycobacterial agent-16 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antimycobacterial agent-16Antimycobacterial agent16Antimycobacterial agent 16Bacterialmycobacterial enoyl-ACP reductase (InhA)multidrug-resistant Mycobacterium tuberculosis strainsHepG2 cellstuberculosisMycobacterium kansasiiMycobacterium tuberculosis H37Rvmycobacterial pyrazinamidaseInhibitorinhibitorinhibit

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