InhA-IN-11
InhA-IN-11 is a Mycobacterium tuberculosis InhA inhibitor with an IC50 of 0.36 μM. InhA-IN-11 exhibits activity against Mycobacterium tuberculosis, disrupts pre-formed Mycobacterium tuberculosis biofilms, and reduces bacterial viability within biofilms. InhA-IN-11 is applicable for the research of tuberculosis.
For research use only. We do not sell to patients.
- Formula: C14H16N4O2S
- Molecular Weight:304.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
140 μg
Compound: 4d
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Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
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[PMID: 24095750] |
InhA-IN-11 (Compound 6) at 0.5 μg/mL potently inhibits the growth of extracellular Mycobacterium tuberculosis H37Rv, with an MIC of 0.5 μg/mL[1].
InhA-IN-11 (40-50 μg/mL; 168-336 h) exhibits bactericidal activity against Mycobacterium tuberculosis H37Rv[1].
InhA-IN-11 (5 μg/mL; 48 h) effectively kills Mycobacterium tuberculosis H37Rv within human monocyte-derived macrophages[1].
InhA-IN-11 (50 μg/mL; 48 h) disrupts preformed Mycobacterium tuberculosis H37Rv biofilms and reduces bacterial viability[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 304.37
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Formula C14H16N4O2S
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SMILES
CCOC(C1=C(N=C(S1)N/N=C(C2=CC=CC=N2)\C)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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