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United States

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Cat. No.: HY-181269

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InhA-IN-11

InhA-IN-11 is a Mycobacterium tuberculosis InhA inhibitor with an IC₅₀ of 0.36 μM. InhA-IN-11 exhibits activity against Mycobacterium tuberculosis, disrupts pre-formed Mycobacterium tuberculosis biofilms, and reduces bacterial viability within biofilms. InhA-IN-11 is applicable for the research of tuberculosis.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₁₄H₁₆N₄O₂S
분자량:304.37

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

InhA-IN-11 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
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Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	140 μg Compound: 4d	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 24095750]

In Vitro

InhA-IN-11 (Compound 6) at 0.5 μg/mL potently inhibits the growth of extracellular Mycobacterium tuberculosis H37Rv, with an MIC of 0.5 μg/mL^[1].
InhA-IN-11 (40-50 μg/mL; 168-336 h) exhibits bactericidal activity against Mycobacterium tuberculosis H37Rv^[1].
InhA-IN-11 (5 μg/mL; 48 h) effectively kills Mycobacterium tuberculosis H37Rv within human monocyte-derived macrophages^[1].
InhA-IN-11 (50 μg/mL; 48 h) disrupts preformed Mycobacterium tuberculosis H37Rv biofilms and reduces bacterial viability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 304.37
화학식 C₁₄H₁₆N₄O₂S
SMILES

CCOC(C1=C(N=C(S1)N/N=C(C2=CC=CC=N2)\C)C)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sabt A, et al. Investigation of Potent Anti-Mycobacterium tuberculosis Agents Derived from Pyridine Derivatives Targeting the Enoyl Acyl Carrier Protein Reductase (InhA): Design, Synthesis, and Computational Analysis. Drug Design, Development and Therapy. 2026 Dec 31:1-7.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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