LRRC15 Antibody (YA3182)(PBS only)

Cat. No.: HY-P83437A: Data Sheet User Guide for Antibodies
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LRRC15 Antibody (YA3182) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LRRC15.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

LRRC15 Antibody (YA3182) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LRRC15.

Host

Rabbit

Molecular Weight

Predicted band size: 64 kDa;

Observed band size: 64 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q8TF66

Gene ID

131578 [NCBI]

Immunogen

A synthetic peptide of human LRRC15

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-1:5000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-1:100

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：(Microbial infection) Modulates the ability of SARS-CoV-2 to infect host cells through interaction with the spike protein (PubMed:36228039, PubMed:36735681, PubMed:36757924). Does not act as a SARS-CoV-2 entry receptor but sequesters virions and antagonizes in trans SARS-CoV-2 infection of ACE2(+) cells when expressed on nearby cells (PubMed:36228039, PubMed:36757924)

Subcellular Localization：Cell membrane; Single-pass type I membrane protein

Expression：
Tissue_specificity:Expressed in brain and placenta (PubMed:11785964) . Expressed in lung fibroblasts (PubMed:36228039, PubMed:36757924) . Expressed in chodrocytes (PubMed:34702854)

Induction:In fiboblasts, expression is strongly induced by TGFB1 (PubMed:36735681, PubMed:36757924) . In chodrocytes, expression is induced by IL1B (PubMed:34702854) ; (Microbial infection) In alveolar cells and fibroblasts, expression is induced by Sars-CoV-2 infection

Isoforms & Post-Translational Modification：Q8TF66 has 2 isomers: Q8TF66-1: 64366 Da (predicted); Q8TF66-2: 65022 Da (predicted).

Subunit：(Microbial infection) Interacts with human coronavirus SARS-CoV-2 spike protein (via RBD domain); the interaction is direct and sequesters virions at the cell surface

Research Field

Neuroscience

Synonyms

LIB

Documentation

User Guide for Antibodies (1077 KB)