LRRC15 - leucine rich repeat containing 15 Gene

Also Known as LIB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 131578

About LRRC15

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:194,355,249-194,369,743 (from NCBI)

This gene has 2 transcripts (splice variants), 112 orthologues and 22 paralogues. Broad expression in endometrium (RPKM 1.9), gall bladder (RPKM 1.2) and 15 other tissues.

Summary

Enables Collagen binding activity; fibronectin binding activity; and laminin binding activity. Involved in negative regulation of protein localization to plasma membrane; positive regulation of cell migration; and receptor-mediated virion attachment to host cell. Located in extracellular exosome. Colocalizes with collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]

LRRC15 Products (2)

mRNA Protein Name
NM_001135057.3 NP_001128529.2 leucine-rich repeat-containing protein 15 isoform a precursor
NM_130830.5 NP_570843.2 leucine-rich repeat-containing protein 15 isoform b precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables collagen binding IDA
IDA: Inferred from direct assay
16098915 GOA
enables fibronectin binding IDA
IDA: Inferred from direct assay
16098915 GOA
enables laminin binding IDA
IDA: Inferred from direct assay
16098915 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
36228039 GOA
enables protein sequestering activity IDA
IDA: Inferred from direct assay
36228039 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
18385238 GOA
involved in negative regulation of viral entry into host cell IDA
IDA: Inferred from direct assay
36228039 GOA
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
16098915 GOA
involved in receptor-mediated virion attachment to host cell IDA
IDA: Inferred from direct assay
36228039 GOA
involved in receptor-mediated virion attachment to host cell IMP
IMP: Inferred from mutant phenotype
18385238 GOA
Cellular Component GO Annotation Evidence References Source
is active in apical plasma membrane IDA
IDA: Inferred from direct assay
36228039 GOA
colocalizes with collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
16098915 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
36228039 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRC15 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (81 - 137)

LRR_1

LRR_1: Leucine Rich Repeat (150 - 172)

LRR_8

LRR_8: Leucine rich repeat (175 - 233)

LRR_4

LRR_4: Leucine Rich repeats (2 copies) (246 - 286)

LRR_8

LRR_8: Leucine rich repeat (293 - 353)

LRR_8

LRR_8: Leucine rich repeat (366 - 423)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 581 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat-containing protein 15

  • hLib

Recombinant LRRC15 Proteins

Cat. No. Product Name Accession Purity
HY-P72512 LRRC15 Protein, Human (HEK293, His) Q8TF66-1 (Y22-G538) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76480 LRRC15 Protein, Human (HEK293, Fc) Q8TF66-1 (Y22-G538) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78172 LRRC15 Protein, Human (Biotinylated, HEK293, His-Avi) Q8TF66-1 (Y22-G538) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78486 LRRC15 Protein, Human (HEK293, His-Avi) Q8TF66-1 (Y22-G538) ≥ 95%, as determined by Bis-Tris PAGE.

LRRC15 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83437 LRRC15 Antibody (YA3182) WB, ICC/IF Human, Mouse, Rat
HY-P83437A LRRC15 Antibody (YA3182)(PBS only) WB, ICC/IF Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07808 LRRC15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17927 Lrrc15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24397 Lrrc15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99899 Samrotamab 98.26% Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LRRC15 VGNC VGNC:97483
Bos taurus LRRC15 VGNC VGNC:31001
Rattus norvegicus LRRC15 RGD RGD:70551
Macaca mulatta LRRC15 VGNC VGNC:74322
Canis familiaris LRRC15 VGNC VGNC:42786
Mus musculus LRRC15 MGD MGI:1921738
Others LRRC15 NCBI