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pa28

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Proteasome (1)
By Research Areas:	Cancer (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-162965

Immunoproteasome activator 1	Proteasome	Cancer
Immunoproteasome activator 1 (compound A) is a selective immunoproteasome activator that increases the presentation of individual MHC-I–bound peptides by over 100-fold. Immunoproteasome activator 1 binds to the proteasome structural subunit PSMA1 and promotes the association of the proteasome activator PA28α/β (PSME1/PSME2) with immunoproteasomes .

Species:	Human (4)
Tag:	His (4)
Source:	E. coli (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P75991

	PSME2 Protein, Human (His) Proteasome activator complex subunit 2; REG-beta; pa28beta; pa28b; PSME2	Human	E. coli
	PSME2 Protein, vital for immunoproteasome assembly, is crucial for efficient antigen processing. In collaboration with PSME1, the PA28 activator complex modifies the proteasome's cleavage pattern, actively contributing to class I binding peptide generation. The hexameric ring structure of this heterodimeric complex underscores its significance in orchestrating processes essential for immune responses and antigen presentation. PSME2 Protein, Human (His) is the recombinant human-derived PSME2 protein, expressed by E. coli , with N-His labeled tag.

HY-P76554

	PSME3 Protein, Human (His, solution) Proteasome activator complex subunit 3; REG-gamma; pa28g; PSME3	Human	E. coli
	PSME3 is a subunit of the 11S REG-gamma proteasome modulator that forms a homoheptamer and is essential for activating the trypsin-like subunit of the proteasome and inhibiting the chymotrypsin-like and PGPH subunits. PSME3 promotes MDM2-p53 interaction, leading to p53 degradation and inhibiting apoptosis after DNA damage. PSME3 Protein, Human (His, solution) is the recombinant human-derived PSME3 protein, expressed by E. coli , with N-His labeled tag.

HY-P76554A

	PSME3 Protein, Human (N-His) Proteasome activator complex subunit 3; REG-gamma; pa28g; PSME3	Human	E. coli
	PSME3 is a subunit of the 11S REG-gamma proteasome modulator that forms a homoheptamer and is essential for activating the trypsin-like subunit of the proteasome and inhibiting the chymotrypsin-like and PGPH subunits. PSME3 promotes MDM2-p53 interaction, leading to p53 degradation and inhibiting apoptosis after DNA damage. PSME3 Protein, Human (N-His) is the recombinant human-derived PSME3 protein, expressed by E. coli , with N-His labeled tag.

HY-P75990

	PSME1 Protein, Human (His) Proteasome activator complex subunit 1; REG-alpha; IGUP I-5111; pa28a; IFI5111	Human	E. coli
	The PSME1 protein is critical for immunoproteasome assembly and is essential for efficient antigen processing. As part of the PA28 activator complex, PSME1, together with PSME2, actively enhances the production of class I binding peptides by altering the cleavage pattern of the proteasome. PSME1 Protein, Human (His) is the recombinant human-derived PSME1 protein, expressed by E. coli , with N-6*His labeled tag.

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Host:	Mouse (1) Rabbit (2)
Reactivity:	Human (3) Rat (3) Mouse (3)
Application:	IHC-P (1) ICC/IF (3) IF-Tissue (1) IP (2) WB (3) FC (1) ELISA (1)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (3) Recombinant (2)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P87017

	PSME2 Antibody (YA6710) 11S regulator complex beta subunit antibody; 11S regulator complex subunit beta antibody; Activator of multicatalytic protease subunit 2 antibody; Cell migration inducing protein 22 antibody; MCP activator 31 kD subunit antibody; pa28 beta antibody; pa28b antibody; pa28beta antibody; Proteasome (prosome macropain) activator subunit 2 (pa28 beta) antibody; Proteasome (prosome macropain) activator subunit 2 antibody; 11S regulator complex beta subunit antibody; 11S regulator complex subunit beta antibody; Activator of multicatalytic protease subunit 2 antibody; Cell migration inducing protein 22 antibody; MCP activator 31 kD subunit antibody; pa28 beta antibody; pa28b antibody; pa28beta antibody; Proteasome (prosome macropain) activator subunit 2 (pa28 beta) antibody; Proteasome (prosome macropain) activator subunit 2 antibody; Proteasome activator 28 beta antibody; Proteasome activator 28 subunit beta antibody; Proteasome activator complex subunit 2 antibody; Proteasome activator hpa28 subunit beta antibody; Proteasome activator subunit 2 antibody; PSME 2 antibody; PSME2 antibody; PSME2_HUMAN antibody; REG beta antibody; REG-beta antibody; REGbeta antibody;	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	PSME2 Antibody (YA6710) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PSME2.

HY-P82021

	PSME1 Antibody (YA1766) pa28A; IFI5111; REGalpha; pa28alpha	WB, ICC/IF, IP	Human, Mouse, Rat
	PSME1 Antibody (YA1766) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PSME1.

HY-P85447

	PA28γ Antibody (YA5139) PSME3; Proteasome activator complex subunit 3; 11S regulator complex subunit gamma; REG-gamma; Activator of multicatalytic protease subunit 3; Ki nuclear autoantigen; Proteasome activator 28 subunit gamma; pa28g; pa28gamma	WB, ICC/IF, IP, ELISA, IF-Tissue	Human, Mouse, Rat
	PA28γ Antibody (YA5139) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PA28γ.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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