2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 317

Anticancer agent 317, a Chidamide (HY-109015) derivative, is an apoptosis inducer. Anticancer agent 317 inhibits colony formation, migration, adhesion, invasion, tumor growth, and angiogenesis. Anticancer agent 317 can be used for the research of breast cancer.

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Anticancer agent 317

Anticancer agent 317 Chemical Structure

CAS No. : 3117779-13-9

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Anticancer agent 317 Related Antibodies

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Description

Anticancer agent 317, a Chidamide (HY-109015) derivative, is an apoptosis inducer. Anticancer agent 317 inhibits colony formation, migration, adhesion, invasion, tumor growth, and angiogenesis. Anticancer agent 317 can be used for the research of breast cancer[1].

In Vitro

Anticancer agent 317 (Compound 6e) potently and selectively inhibits proliferation of MDA-MB-231 breast cancer cells with an IC50 of 0.10 μM[1].
Anticancer agent 317 (0.025-0.1 μM; 24 h) dose-dependently inhibits long-term colony formation of MDA-MB-231 breast cancer cells, with significant inhibition observed at concentrations as low as 0.025 μM[1].
Anticancer agent 317 (0.025-0.1 μM; 48 h) dose-dependently induces apoptosis in MDA-MB-231 breast cancer cells, with the highest level of apoptosis observed at 0.1 μM[1].
Anticancer agent 317 (0.01-0.04 μM; 24 h) dose-dependently inhibits adhesion of MDA-MB-231 breast cancer cells, with significant inhibition observed at concentrations as low as 0.01 μM[1].
Anticancer agent 317 (0.01-0.04 μM; 24-48 h) dose-dependently inhibits invasion of MDA-MB-231 breast cancer cells, with significant inhibition observed at concentrations as low as 0.01 μM[1].
Anticancer agent 317 (0.025-0.1 μM) dose-dependently inhibits angiogenesis and tumor growth in a chicken embryo CAM model of breast cancer, with the 0.1 μM dose reducing tumor weight to 8.33 mg and angiogenesis to 51.79% of control levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 317 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231
Concentration: 0.025 μM; 0.05 μM; 0.1 μM
Incubation Time: 24 h
Result: Dose-dependently reduced colony-forming ability of MDA-MB-231 cells, with colony formation rates of 66.17% at 0.025 μM, 50.00% at 0.05 μM, and 33.46% at 0.1 μM.
Showed stronger inhibitory activity than chidamide (86.07% colony formation rate) at 0.1 μM.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231
Concentration: 0.025 μM; 0.05 μM; 0.1 μM
Incubation Time: 48 h
Result: Dose-dependently increased the proportion of Annexin V-positive apoptotic cells.
Markedly elevated the proportion of apoptotic cells (Annexin V-positive, PI-positive/negative) compared to untreated control at 0.1 μM, with 21.16% of cells in the early apoptotic quadrant and 29.33% in the late apoptotic quadrant.

Cell Migration Assay [1]

Cell Line: MDA-MB-231
Concentration: 0.01 μM; 0.02 μM; 0.04 μM
Incubation Time: 24 h; 48 h
Result: Inhibited migration capacity at both 24 h and 48 h.
Reduced migration rates to 66.65% at 0.01 μM, 50.42% at 0.02 μM, and 30.99% at 0.04 μM after 48 h.
Showed stronger inhibitory activity than chidamide (51.69% migration rate at 48 h) at 0.04 μM.
Molecular Weight

872.45

Formula

C47H47ClFN9O3S
CAS No.
SMILES

CC1=NN=C2[C@@H](N=C(C3=C(N12)SC(C)=C3C)C4=CC=C(C=C4)Cl)CC(NCCCCCCNC5=CC(F)=CC=C5NC(C6=CC=C(C=C6)CNC(/C=C/C7=CC=CN=C7)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Anticancer agent 317 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 3173117779-13-9Anticancer agent317Anticancer agent-317Apoptosisbreast cancertumor growthBRD4apoptosisMDA-MB-231 breast cancer cellscolony formationadhesioninvasionangiogenesismigrationInhibitorinhibitorinhibit

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