Antitumor photosensitizer-11
Antitumor photosensitizer-11 is a type-I carbazole/benzindolium photosensitizer with antitumor activity. Antitumor photosensitizer-11 induces ROS generation via a type-I pathway, forming superoxide anions and hydroxyl radicals. Antitumor photosensitizer-11 triggers immunogenic cell death in cancer cells via enhanced oxidative stress. Antitumor photosensitizer-11 exhibits antiproliferative activity in normoxic and hypoxic environments, inhibits breast cancer tumor growth in vivo, and promotes dendritic cell maturation and T cell infiltration. Antitumor photosensitizer-11 can be used for the research of cancer, such as breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 2813319-14-9
- Formula: C28H22IN3O2
- Molecular Weight:559.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Antitumor photosensitizer-11 (Compound 3a) acts as a photosensitizer, generating high levels of total ROS, superoxide anions, and hydroxyl radicals with minimal singlet oxygen production upon 520 nm light exposure[1].
Antitumor photosensitizer-11 (24 h) exhibits chemotherapeutic antiproliferative activity against normoxic 4T1 cells with an IC50 of 20.1 μM, and this activity is enhanced by 520 nm light exposure to an IC50 of 2.8 μM[1].
Antitumor photosensitizer-11 (24 h) exhibits chemotherapeutic antiproliferative activity against normoxic A549 cells with an IC50 of 9.4 μM, and this activity is enhanced by 520 nm light exposure to an IC50 of 3.1 μM[1].
Antitumor photosensitizer-11 (24 h) exhibits chemotherapeutic antiproliferative activity against normoxic HT29 cells with an IC50 of 15.1 μM, and this activity is enhanced by 520 nm light exposure to an IC50 of 2.8 μM[1].
Antitumor photosensitizer-11 (24 h) exhibits chemotherapeutic antiproliferative activity against hypoxic 4T1 cells with an IC50 of 15.4 μM, and this activity is enhanced by 520 nm light exposure to an IC50 of 2.4 μM[1].
Antitumor photosensitizer-11 (24 h) exhibits chemotherapeutic antiproliferative activity against hypoxic A549 cells with an IC50 of 18.5 μM, and this activity is enhanced by 520 nm light exposure to an IC50 of 5.5 μM[1].
Antitumor photosensitizer-11 (24 h) exhibits chemotherapeutic antiproliferative activity against hypoxic HT29 cells with an IC50 of 19.4 μM, and this activity is enhanced by 520 nm light exposure to an IC50 of 4.3 μM[1].
Antitumor photosensitizer-11 is stable in PBS, DMEM, and pH 5-7 solutions for up to 12 hours, and exhibits strong photostability after 10 min of 520 nm light exposure[1].
Antitumor photosensitizer-11 induces significant intracellular total ROS and superoxide anion generation in 4T1 cells only when combined with 520 nm light exposure, under both normoxic and hypoxic conditions[1].
Antitumor photosensitizer-11 (20 μM) combined with 520 nm light exposure induces immunogenic cell death in 4T1 cells, as evidenced by increased CRT exposure, decreased HMGB1 release, and ~15.86-fold higher ATP secretion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:normoxic 4T1 murine breast cancer cells
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Concentration:20.1 μM (without light); 2.8 μM (with light)
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Incubation Time:24 h
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Result:Inhibited 4T1 cell growth with an IC50 of 20.1 μM without light.
Enhanced antiproliferative activity with an IC50 of 2.8 μM with 520 nm light exposure.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Breast cancer BALB/c mice(female, inoculated with 4T1 tumor cells)[1]
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Dosage:5 mg/kg
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Administration:Intratumoral injection; on day 0, 3, 6, 9, 12 with 520 nm laser irradiation (60 J/cm2)
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Result:Achieved a 75.8% tumor growth inhibition rate, reduced tumor weight by 71.8% versus the PBS group, and increased tumor apoptosis relative to PBS.
Achieved a 93.1% tumor growth inhibition rate when combined with 520 nm laser irradiation, reduced tumor weight by 89.4% versus the PBS group, increased tumor apoptosis to over 60%.
Reduced Ki67 proliferation marker expression to near baseline levels, increased CD80+CD86+ mature dendritic cells to 33.4% in tumor-associated lymph nodes and 38.2% in tumor sites, and raised CD3+CD8+ T cell proportion to 34.1% in tumor-associated lymph nodes when combined with 520 nm laser irradiation.
Showed liver (ALT, AST) and kidney (creatinine, BUN, uric acid) biomarker levels comparable to PBS controls, with no histopathological organ damage observed.
Reached a median lethal dose (LD50) of 82.2 mg/kg in mice.
Chemical Information
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CAS No. 2813319-14-9
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Molecular Weight 559.40
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Formula C28H22IN3O2
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SMILES
CCN1C2=CC=C([N+]([O-])=O)C=C2C3=C1C=CC(/C=C/C4=[N+](C)C5=CC=CC6=CC=CC4=C56)=C3.[I-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor photosensitizer-11 Related Classifications
HY-183570 Related Classifications
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Keywords
- Antitumor photosensitizer-11
- 2813319-14-9
- Antitumor photosensitizer11
- Antitumor photosensitizer 11
- Photosensitizer
- Reactive Oxygen Species (ROS)
- lung cancer
- breast cancer
- hydroxyl radicals
- 4T1 cells
- reactive oxygen species
- hypoxic tumors
- A549 cells
- immunogenic cell death
- colon cancer
- superoxide anions
- Inhibitor
- inhibitor
- inhibit