Antiviral agent 15 

Antiviral agent 15 (Compound 15f) is a Clofazimine derivative with antiviral effects. Antiviral agent 15 inhibits both rabies virus and pseudo-typed SARS-CoV-2 with EC₅₀ values of 1.45 μM and 14.6 μM, respectively^[1].

Antiviral agent 15 (Compound 15f) affects the rabies and SARS-CoV-2 proliferation by targeting G or S protein to block the viral membrane fusion, as well as binding to L protein or nsp13 to inhibit viral biosynthesis, respectively, and thus synergistically exerted antiviral effect^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Kunming mice, Antiviral agent 15 (Compound 15f) is given orally in a single-dosing experiment at 0 mg/kg, 200 mg/kg, 400 mg/kg, 600 mg/kg and 800 mg/kg, respectively. The mice are closely monitored for 7 days, and all the surviving mice had glossy hair, fleshy body and good appetite^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

453.51

C₂₇H₂₄FN₅O

COC1=CC=C(N=C1)N2C3=CC=CC=C3N=C4C=C(/C(C=C42)=N/C(C)C)NC5=CC(F)=CC=C5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Xintong Zhang, et al. Clofazimine derivatives as potent broad-spectrum antiviral agents with dual-target mechanism. Eur J Med Chem. 2022 Apr 15;234:114209.  [Content Brief]