Apoptosis inducer 7

Cat. No.: HY-149017: Ficha de datos Instrucciones de manejo
FAQs
Technical Support

Apoptosis inducer 7 (Compound 5I) induces apoptosis in cancer cells. Apoptosis inducer 7 inducrs cleavage of PARP, caspases, down-regulation of anti-apoptotic protein c-Flip and up regulation of pro-apoptotic protein Noxa. Apoptosis inducer 7 exhibits antitumor activity.

Para uso exclusivo en investigación. No vendemos a pacientes.

Apoptosis inducer 7 Estructura química

No. CAS : 2252278-57-0

Tamaño		Stock
MOQ		Minimum order quantity
50 mg		Obtener un presupuesto
100 mg		Obtener un presupuesto
250 mg		Obtener un presupuesto
Other size		Obtener un presupuesto

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

1 Publications Citing Use of MCE Apoptosis inducer 7

•Bone Res. 2024 Aug 27;12(1):47. [Abstract]

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

In Vitro

Apoptosis inducer 7 (Compound 5I) (0.098-50 μM, 96 hours; human tumor cell lines) exerts the most potent antitumor activities against human cancer cell lines^[1].
Apoptosis inducer 7 (Compound 5I) induces apoptosis in HCT-116 cells, and the apoptosis induction is related to the downregulation of anti-apoptotic protein c-Flip and upregulation of pro-apoptotic protein Noxa^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	Human breast cancer MDA-MB-231 cells, human lung cancer A549 cells, human colorectal cancer HCT-116 cells, human liver cancer HepG-2 cells and one non-tumor human breast epithelial MCF-10A cells.
Concentration:	0.098-50 μM
Incubation Time:	96 hours
Result:	Inhibited with IC₅₀ values of 0.22, 0.15, 0.42, 0.14 and 1.03 μM for MDA-MB-231, A549, HCT-116, HepG-2 and MCF-10A, respectively.

Cell Cycle Analysis^[1]

Cell Line:	HCT-116 cells
Concentration:	0.5, 0.75 and 1.0 μM
Incubation Time:	24 hours
Result:	More than 40% of the cells were detected in the sub G1 phase.

Western Blot Analysis^[1]

Cell Line:	HCT-116 cells
Concentration:	0.5, 0.75 and 1.0 μM
Incubation Time:	24 hours
Result:	Induced cleavage of PARP, caspases and decreased the levels of c-Flip and HDAC3 proteins.

In Vivo

Apoptosis inducer 7 (Compound 5I) (5 mg/kg; i.p.; three times a week, for 14 days; LL/2 xenograft model in C57/ BL6J mice) inhibits tumor growth^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	KARPAS-422 subcutaneous xenograft in mice^[1]
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; three times a week, for 14 days.
Result:	Inhibited the tumor growth with an inhibition rate of 62.3%, without significant body weight loss.

Peso molecular

797.07

Fòrmula

C₄₉H₆₈N₂O₇

No. CAS

2252278-57-0

SMILES

C[C@]12[C@@](C(C=C3[C@]2(CC[C@@]4([C@@]3([H])C[C@](C)(CC4)C(OCC5=CC=CC=C5)=O)C)C)=O)([H])[C@@]6([C@@](C(C)(C(/C(C6)=C/C(NC7CCN(CC7)C(OC(C)(C)C)=O)=O)=O)C)([H])CC1)C

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Huang M, et al. Synthesis and antitumor effects of novel 18β-glycyrrhetinic acid derivatives featuring an exocyclic α,β-unsaturated carbonyl moiety in ring A. Bioorg Chem. 2020 Oct;103:104187. [Content Brief]