2. Neuronal Signaling
  3. Tau Protein
  4. Armanezumab

Armanezumab is a monoclonal antibody that targets and inhibits tau protein, and it specifically binds to the exposed N-terminal domain of pathological tau protein. Armanezumab can be used in relevant studies on Alzheimer's disease, frontotemporal dementia, and Pick's disease.

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Armanezumab

Armanezumab Chemical Structure

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Armanezumab Related Antibodies

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Description

Armanezumab is a monoclonal antibody that targets and inhibits tau protein, and it specifically binds to the exposed N-terminal domain of pathological tau protein. Armanezumab can be used in relevant studies on Alzheimer's disease, frontotemporal dementia, and Pick's disease[1].

Species Reactivity

Human
In Vitro

Armanezumab (3-243 nM) binds recombinant human 0N/4R tau protein with a high affinity, characterized by an equilibrium dissociation constant of 38.8 nM[1].
Armanezumab (0.02-12.5 μM; 1.5 h) specifically targets the PRQEF epitope (amino acids 4-8) of tau2-18, with amino acids 6 (glutamine) and 7 (glutamic acid) being essential for binding[1].
Armanezumab (1 μM; 16 h) partially protects SH-SY5Y human neuroblastoma cells from tau oligomer-mediated cytotoxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Armanezumab Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: SH-SY5Y human neuroblastoma cells
Concentration: 1 μM (Armanezumab pre-incubated with 0.5 μM tau oligomers)
Incubation Time: 16 h (cell incubation with oligomer-Armanezumab mixture)
Result: Restored SH-SY5Y cell viability to 89% compared to 36% viability in cells treated with tau oligomers alone, protecting cells from tau oligomer-mediated cytotoxicity.
In Vivo

Armanezumab (2 μg; intracranial injection; single dose) reduces total and multiple phosphorylated pathological tau species in the brains of THY-Tau22 tau transgenic mice 5 days after administration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: THY-Tau22 tau transgenic mice (6-month-old)[1]
Dosage: 2 μg
Administration: intracranial injection (hippocampus and cortex); single dose
Result: Reduced total tau (HT7-stained) and phosphorylated tau species including pThr212, pSer214, pSer396/pSer404 (PHF1-stained), pThr212/pSer214 (AT100-stained), pThr231 (AT180-stained), and pSer202/pThr205 (AT8-stained) in the ipsilateral hemisphere compared to contralateral control IgG-injected hemisphere.
Confirmed neuronal integrity at injection sites via anti-NeuN staining.
Gene ID

4137  [NCBI]

Accession
Target

Tau
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

[Armanezumab]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Armanezumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ArmanezumabTau ProteinN-terminal domain of pathological tautau transgenic mouseHEK293 cellsAlzheimer's diseaseCHO-DG44 cell lineHEK293T cellsPick's diseasefrontotemporal dementiapathological tauSH-SY5Y human neuroblastoma cellsInhibitorinhibitorinhibit

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