2. GPCR/G Protein
  3. Endothelin Receptor
  4. ATZ-1993

ATZ-1993 is an orally active, nonpeptide endothelin receptor subtype Aand endothelin receptor subtype B antagonist with pKi values of 8.69, 7.20, respectively. ATZ-1993 has the potential for the research of intimal hyperplasia after balloon denudation of the carotid artery.

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ATZ-1993

ATZ-1993 화학구조

CAS No. : 219705-77-8

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제품 설명

ATZ-1993 is an orally active, nonpeptide endothelin receptor subtype Aand endothelin receptor subtype B antagonist with pKi values of 8.69, 7.20, respectively. ATZ-1993 has the potential for the research of intimal hyperplasia after balloon denudation of the carotid artery[1].

IC50 & Target[1]

ETA

8.69 (pKi)

ETB

7.20 (pKi)

In Vivo

ATZ-1993 (30 mg/kg; drinking water, daily for 1 week) inhibits the intimal hyperplasia intimal hyperplasia after balloon denudation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Japanese White male rabbits[1]
Dosage: 30 mg/kg
Administration: Drinking water, daily for 1 weeks
Result: Inhibited the intimal hyperplasia with the inhibition rate approximately 77%, increased in intima:media ratio and DNA content.
분자량

484.55

화학식

C28H28N4O4
CAS No.
SMILES

O=C(C1=NN(C(C2=CC=CC(OCC)=C2)CC)C3=C1CCC4=CC(OCC5=CN=CN=C5)=CC=C43)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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ATZ-1993 Related Classifications

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Keywords:

ATZ-1993219705-77-8ATZ1993ATZ 1993Endothelin Receptorcarotid artery balloon denudationorally activeintimal hyperplasiaInhibitorinhibitorinhibit

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상품명:
ATZ-1993
Cat. No.:
HY-122237
수량:
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