2. Epigenetics
  3. MicroRNA
  4. Benzazepinoquinoline-spermine

Benzazepinoquinoline-spermine (Compound PA-3) is an efficient pre-miR-372 complexing agent, and it can specifically inhibit its processing mediated by Dicer. Its IC₅₀ value is 0.58 μM. Benzazepinoquinoline-spermine has a strong affinity for pre-miR-372, with a KD value of 0.11 μM. Benzazepinoquinoline-spermine also shows high activity against pre-miR-373 (IC₅₀ = 0.29 μM), but significantly reduced inhibitory activity against pre-miR-17, pre-miR-21, and pre-miR-155 (IC₅₀ being 0.84 μM, 1.43 μM, and 1.07 μM respectively). Benzazepinoquinoline-spermine can be used for cancer research.

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Benzazepinoquinoline-spermine

Benzazepinoquinoline-spermine 構造式

CAS 番号 : 2250121-20-9

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Benzazepinoquinoline-spermine 関連抗体

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製品説明

Benzazepinoquinoline-spermine (Compound PA-3) is an efficient pre-miR-372 complexing agent, and it can specifically inhibit its processing mediated by Dicer. Its IC₅₀ value is 0.58 μM. Benzazepinoquinoline-spermine has a strong affinity for pre-miR-372, with a KD value of 0.11 μM. Benzazepinoquinoline-spermine also shows high activity against pre-miR-373 (IC₅₀ = 0.29 μM), but significantly reduced inhibitory activity against pre-miR-17, pre-miR-21, and pre-miR-155 (IC₅₀ being 0.84 μM, 1.43 μM, and 1.07 μM respectively). Benzazepinoquinoline-spermine can be used for cancer research[1].

分子量

504.75

分子式

C31H48N6
CAS 番号
SMILES

C[C@@]12[C@@](C(NCCCNCCCCNCCCN)=NC3=CC=CC=C31)(CC(C4=CC=CC=C4N2C)C)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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Benzazepinoquinoline-spermine Related Classifications

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Keywords:

Benzazepinoquinoline-spermine2250121-20-9MicroRNAmiRNAicroRNA biogenesisheterocycle-spermine conjugatespre-miR-372Dicer inhibitionRNA bindersmolecular dockingselectivitythermodynamic profilingInhibitorinhibitorinhibit

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製品名:
Benzazepinoquinoline-spermine
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