Biotinyl-NH-PEG3-C3-amido-C3-COOH

Name: Biotinyl-NH-PEG3-C3-amido-C3-COOH
Brand: MedChemExpress
SKU: HY-130142A
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Cat. No.: HY-130142A Pureté: 99.25%: Fiche technique
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Biotinyl-NH-PEG3-C3-amido-C3-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

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Biotinyl-NH-PEG3-C3-amido-C3-COOH Chemical Structure

CAS No. : 1202761-21-4

Size	Stock	Quantité
Échantillon gratuit (0.1 - 0.2 mg)	Appliquer maintenant
Échantillon gratuit (0.1 - 0.2 mg)	Appliquer maintenant
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtenir un devis
500 mg	Obtenir un devis

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Other Forms of Biotinyl-NH-PEG3-C3-amido-C3-COOH:

Biotinyl-NH-PEG3-C3-amido-C3-COOH (DIPEA) Obtenir un devis

Recommandations en vedette

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform PROTAC Linkers:

Voir toutes les isoformes

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Activité biologique
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Description

Biotinyl-NH-PEG3-C3-amido-C3-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Masse moléculaire

560.70

Formule

C₂₅H₄₄N₄O₈S

CAS No.

1202761-21-4

Appearance

Solid

Color

White to off-white

SMILES

OC(CCCC(NCCCOCCOCCOCCCNC(CCCC[C@H]1[C@]2([H])[C@](NC(N2)=O)([H])CS1)=O)=O)=O

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

DMSO : 250 mg/mL (445.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Methanol : ≥ 100 mg/mL (178.35 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7835 mL	8.9174 mL	17.8348 mL
5 mM	0.3567 mL	1.7835 mL	3.5670 mL
10 mM	0.1783 mL	0.8917 mL	1.7835 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité
Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureté et documentation

Purity: 99.25%

Select Batch:

Fiche technique (266 KB) SDS (252 KB)

COA (241 KB) HNMR (274 KB) LCMS (85 KB)

Instruction de manipulation (2659 KB)

Références

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Methanol / DMSO	1 mM	1.7835 mL	8.9174 mL	17.8348 mL	44.5871 mL
	5 mM	0.3567 mL	1.7835 mL	3.5670 mL	8.9174 mL
	10 mM	0.1783 mL	0.8917 mL	1.7835 mL	4.4587 mL
	15 mM	0.1189 mL	0.5945 mL	1.1890 mL	2.9725 mL
	20 mM	0.0892 mL	0.4459 mL	0.8917 mL	2.2294 mL
	25 mM	0.0713 mL	0.3567 mL	0.7134 mL	1.7835 mL
	30 mM	0.0594 mL	0.2972 mL	0.5945 mL	1.4862 mL
	40 mM	0.0446 mL	0.2229 mL	0.4459 mL	1.1147 mL
	50 mM	0.0357 mL	0.1783 mL	0.3567 mL	0.8917 mL
	60 mM	0.0297 mL	0.1486 mL	0.2972 mL	0.7431 mL
	80 mM	0.0223 mL	0.1115 mL	0.2229 mL	0.5573 mL
	100 mM	0.0178 mL	0.0892 mL	0.1783 mL	0.4459 mL