2. Protein Tyrosine Kinase/RTK
  3. SHP1 SHP2
  4. BPDA2

BPDA2 is a highly selective and competitive active site SHP2 inhibitor with IC50s of 92.0 nM, 33.39 μM, 40.71 μM for SHP2, SHP1, SHP1B, respectively. DBDA2 downregulates mitogenic and cell survival signaling and RTK expression. BPDA2 suppresses SHP2 mediated signaling and breast cancer cell phenotypes.

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BPDA2

BPDA2 화학구조

CAS No. : 2907659-86-1

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5 mg 해외재고보유
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BPDA2 Related Antibodies

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제품 설명

BPDA2 is a highly selective and competitive active site SHP2 inhibitor with IC50s of 92.0 nM, 33.39 μM, 40.71 μM for SHP2, SHP1, SHP1B, respectively. DBDA2 downregulates mitogenic and cell survival signaling and RTK expression. BPDA2 suppresses SHP2 mediated signaling and breast cancer cell phenotypes[1].

In Vitro

BPDA2 (0.2-3.2 μM) inhibits basal activation of Akt and ERK1/2 in a concentration dependent manner[1].
BPDA2 (0.25-4.0 μM; for 10 days) suppresses the anchorage independent growth and cancer stem cell properties of breast cancer cells in a concentration dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BPDA2 Related Antibodies

Western Blot Analysis[1]

Cell Line: JIMT-1, MDA-MB468 cell
Concentration: 0.2, 0.4, 0.8, 1.6, 3.2 μM
Incubation Time:
Result: Inhibited basal activation of Akt and ERK1/2 in a concentration dependent manner.
분자량

398.49

화학식

C24H30O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCOC1=CC=C(C=C1C(O)=O)C2=CC=C(C=C2)CC(O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
순도&문서
References
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BPDA2 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BPDA22907659-86-1BPDA 2BPDA-2SHP1SHP2Shp1PTPN6Src homology region 2 (SH-2) domain-containing phosphatase 1Src homology phosphatase 2PTPN11CompetitiveSHP1BmitogenicRTKbreast cancerJIMT-1MDA-MB468Inhibitorinhibitorinhibit

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상품명:
BPDA2
Cat. No.:
HY-152208
수량:
MCE Japan Authorized Agent:

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