Brecanavir (Synonyms: GW640385)

Cat. No.: HY-121240 Purity: 98.79%: Data Sheet
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Brecanavir (GW640385) is a novel, potent HIV protease inhibitor.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Brecanavir 화학구조

CAS No. : 313682-08-5

사이즈	재고	수량
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	견적 받기	Estimated Time of Arrival: December 31
10 mg	견적 받기
50 mg	견적 받기

or 대량구매 문의

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

Brecanavir (GW640385) is a novel, potent HIV protease inhibitor.

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	EC₅₀	>90000 nM Compound: BCV, GW-640385	Antiviral activity against HIV1 HXB2 in human HeLa cells by HeLa-CD4 MAGI assay Antiviral activity against HIV1 HXB2 in human HeLa cells by HeLa-CD4 MAGI assay	[PMID: 17620375]
HeLa	EC₅₀	>90 μM Compound: BCV, GW-640385	Antiviral activity against HIV1 HXB2 in human HeLa cells by HeLa-CD4 MAGI assay Antiviral activity against HIV1 HXB2 in human HeLa cells by HeLa-CD4 MAGI assay	[PMID: 17620375]
MDCK-II	IC₅₀	24.1 μM Compound: BRV	Inhibition of human MDR1-dependent accumulation of calcein-AM expressed in MDCK2 cells Inhibition of human MDR1-dependent accumulation of calcein-AM expressed in MDCK2 cells	[PMID: 17664327]
MT2	IC₅₀	0.0002 μM Compound: BCV, brecanavir	Antiviral activity against HIV1 LAI in MT2 cells Antiviral activity against HIV1 LAI in MT2 cells	[PMID: 17635930]
MT2	IC₅₀	0.2 nM Compound: BCV, brecanavir	Antiviral activity against HIV1 LAI in MT2 cells Antiviral activity against HIV1 LAI in MT2 cells	[PMID: 17635930]
MT4	EC₅₀	0.44 nM Compound: BCV, GW-640385	Antiviral activity against HIV1 3B in human MT4 cells assessed as inhibition of viral-induced viral cytopathic effect by MTS assay Antiviral activity against HIV1 3B in human MT4 cells assessed as inhibition of viral-induced viral cytopathic effect by MTS assay	[PMID: 17620375]
MT4	EC₅₀	0.53 nM Compound: BCV, GW-640385	Antiviral activity against HIV1 HXB2 in human MT4 cells assessed as inhibition of viral-induced viral cytopathic effect by MTS assay Antiviral activity against HIV1 HXB2 in human MT4 cells assessed as inhibition of viral-induced viral cytopathic effect by MTS assay	[PMID: 17620375]
MT4	EC₅₀	0.7 nM Compound: BCV, GW-640385	Antiviral activity against HIV1 HXB2 in human MT4 cells assessed as inhibition of viral-induced viral cytopathic effect in presence of 10% fetal bovine serum by MTS assay Antiviral activity against HIV1 HXB2 in human MT4 cells assessed as inhibition of viral-induced viral cytopathic effect in presence of 10% fetal bovine serum by MTS assay	[PMID: 17620375]
MT4	EC₅₀	1.1 nM Compound: BCV, GW-640385	Antiviral activity against HIV1 HXB2 in human MT4 cells assessed as inhibition of viral-induced viral cytopathic effect in presence of 40% fetal bovine serum by MTS assay Antiviral activity against HIV1 HXB2 in human MT4 cells assessed as inhibition of viral-induced viral cytopathic effect in presence of 40% fetal bovine serum by MTS assay	[PMID: 17620375]
MT4	EC₅₀	1.4 nM Compound: BCV, GW-640385	Antiviral activity against HIV1 HXB2 in human MT4 cells assessed as inhibition of viral-induced viral cytopathic effect in presence of 10% fetal bovine serum and 10% human serum by MTS assay Antiviral activity against HIV1 HXB2 in human MT4 cells assessed as inhibition of viral-induced viral cytopathic effect in presence of 10% fetal bovine serum and 10% human serum by MTS assay	[PMID: 17620375]
MT4	EC₅₀	2.2 nM Compound: BCV, GW-640385	Antiviral activity against HIV1 HXB2 in human MT4 cells assessed as inhibition of viral-induced viral cytopathic effect in presence of 10% fetal bovine serum and 20% human serum by MTS assay Antiviral activity against HIV1 HXB2 in human MT4 cells assessed as inhibition of viral-induced viral cytopathic effect in presence of 10% fetal bovine serum and 20% human serum by MTS assay	[PMID: 17620375]
MT4	EC₅₀	2.6 nM Compound: BCV, GW-640385	Antiviral activity against HIV1 HXB2 in human MT4 cells assessed as inhibition of viral-induced viral cytopathic effect in presence of 10% fetal bovine serum and 30% human serum by MTS assay Antiviral activity against HIV1 HXB2 in human MT4 cells assessed as inhibition of viral-induced viral cytopathic effect in presence of 10% fetal bovine serum and 30% human serum by MTS assay	[PMID: 17620375]
MT4	EC₅₀	3.8 nM Compound: BCV, GW-640385	Antiviral activity against HIV1 HXB2 in human MT4 cells assessed as inhibition of viral-induced viral cytopathic effect in presence of 10% fetal bovine serum and 40% human serum by MTS assay Antiviral activity against HIV1 HXB2 in human MT4 cells assessed as inhibition of viral-induced viral cytopathic effect in presence of 10% fetal bovine serum and 40% human serum by MTS assay	[PMID: 17620375]
MT4	IC₅₀	0.22 nM Compound: 27	Antiviral activity against HIV1 I54V in MT4 cells Antiviral activity against HIV1 I54V in MT4 cells	[PMID: 16458505]
MT4	IC₅₀	0.45 nM Compound: 27	Antiviral activity against nelfinavir resistant HIV1 14330 in MT4 cells Antiviral activity against nelfinavir resistant HIV1 14330 in MT4 cells	[PMID: 16458505]
MT4	IC₅₀	0.46 nM Compound: 27	Antiviral activity against indinavir resistant HIV1 30813 in MT4 cells Antiviral activity against indinavir resistant HIV1 30813 in MT4 cells	[PMID: 16458505]
MT4	IC₅₀	0.7 nM Compound: 27	Antiviral activity against HIV1 HXB2 in MT4 cells Antiviral activity against HIV1 HXB2 in MT4 cells	[PMID: 16458505]
MT4	IC₅₀	0.77 nM Compound: 27	Antiviral activity against multi PI resistant HIV1 EP14 in MT4 cells Antiviral activity against multi PI resistant HIV1 EP14 in MT4 cells	[PMID: 16458505]
MT4	IC₅₀	1.1 nM Compound: 27	Antiviral activity against HIV1 EP13 in MT4 cells Antiviral activity against HIV1 EP13 in MT4 cells	[PMID: 16458505]
MT4	IC₅₀	1.6 nM Compound: 27	Antiviral activity against HIV1 I50V in MT4 cells Antiviral activity against HIV1 I50V in MT4 cells	[PMID: 16458505]
MT4	IC₅₀	1.7 nM Compound: 27	Antiviral activity against multi PI resistant HIV1 31246 in MT4 cells Antiviral activity against multi PI resistant HIV1 31246 in MT4 cells	[PMID: 16458505]
MT4	IC₅₀	4.8 nM Compound: 27	Antiviral activity against HIV D545701 in MT4 cells Antiviral activity against HIV D545701 in MT4 cells	[PMID: 16458505]
MT4	IC₅₀	5.4 nM Compound: 27	Antiviral activity against triple multi PI resistant HIV1 in MT4 cells Antiviral activity against triple multi PI resistant HIV1 in MT4 cells	[PMID: 16458505]
MT4	IC₅₀	8.2 nM Compound: 27	Antiviral activity against amprenavir resistant HIV1 468 in MT4 cells Antiviral activity against amprenavir resistant HIV1 468 in MT4 cells	[PMID: 16458505]

Clinical Trial

분자량

703.82

화학식

C₃₃H₄₁N₃O₁₀S₂

CAS No.

313682-08-5

Appearance

Solid

Color

White to off-white

SMILES

CC1=NC(COC2=CC=C(C[C@H](NC(O[C@H]3CO[C@@H]4[C@H]3CCO4)=O)[C@H](O)CN(S(=O)(C5=CC=C6C(OCO6)=C5)=O)CC(C)C)C=C2)=CS1

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

용액&용해도

In Vitro:

DMSO : 17.6 mg/mL (25.01 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4208 mL	7.1041 mL	14.2082 mL
5 mM	0.2842 mL	1.4208 mL	2.8416 mL
10 mM	0.1421 mL	0.7104 mL	1.4208 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 98.79%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (255 KB) HNMR (238 KB) LCMS (343 KB)

Handling Instructions (2659 KB)

References

[1]. Ford SL, Reddy YS, Anderson MT, et al. Single-dose safety and pharmacokinetics of brecanavir, a novel human immunodeficiency virus protease inhibitor. Antimicrob Agents Chemother. 2006;50(6):2201-2206. [Content Brief]

[2]. Reddy YS, Ford SL, Anderson MT, Murray SC, Ng-Cashin J, Johnson MA. Safety and pharmacokinetics of brecanavir, a novel human immunodeficiency virus type 1 protease inhibitor, following repeat administration with and without ritonavir in healthy adult subj [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4208 mL	7.1041 mL	14.2082 mL	35.5204 mL
	5 mM	0.2842 mL	1.4208 mL	2.8416 mL	7.1041 mL
	10 mM	0.1421 mL	0.7104 mL	1.4208 mL	3.5520 mL
	15 mM	0.0947 mL	0.4736 mL	0.9472 mL	2.3680 mL
	20 mM	0.0710 mL	0.3552 mL	0.7104 mL	1.7760 mL
	25 mM	0.0568 mL	0.2842 mL	0.5683 mL	1.4208 mL

Brecanavir Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Brecanavir313682-08-5GW640385GW 640385GW-640385HIV ProteaseInhibitorinhibitorinhibit

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Brecanavir (Synonyms: GW640385)

고객리뷰

Brecanavir Related Antibodies

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•Related Proteins:

Biological Activity

순도&문서

References

고객리뷰

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Brecanavir Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

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