2. Metabolic Enzyme/Protease
  3. Glycosidase
  4. C2 Adamantanyl glucosylceramide (d18:1/2:0)

C2 Adamantanyl glucosylceramide (d18:1/2:0)  (Synonyms: Adamantanyl GluCer (d18:1/2:0); Adamantanyl glucosylceramide (d18:1/2:0); AdaGluCer (d18:1/2:0))

Cat. No.: HY-181469
Handling Instructions Technical Support

C2 Adamantanyl glucosylceramide (d18:1/2:0) (Adamantanyl GluCer (d18:1/2:0)) is an inhibitor of glucocerebrosidase (GCC) and LacCer synthase. At low doses, C2 Adamantanyl glucosylceramide (d18:1/2:0) increases intracellular glycolipid levels by inhibiting glucocerebrosidase. C2 Adamantanyl glucosylceramide (d18:1/2:0) alters glycolipid metabolism. C2 Adamantanyl glucosylceramide (d18:1/2:0) can be used for the research of Gaucher disease and Fabry disease.

For research use only. We do not sell to patients.

C2 Adamantanyl glucosylceramide (d18:1/2:0)

C2 Adamantanyl glucosylceramide (d18:1/2:0) Chemical Structure

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C2 Adamantanyl glucosylceramide (d18:1/2:0) Related Antibodies

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Description

C2 Adamantanyl glucosylceramide (d18:1/2:0) (Adamantanyl GluCer (d18:1/2:0)) is an inhibitor of glucocerebrosidase (GCC) and LacCer synthase. At low doses, C2 Adamantanyl glucosylceramide (d18:1/2:0) increases intracellular glycolipid levels by inhibiting glucocerebrosidase. C2 Adamantanyl glucosylceramide (d18:1/2:0) alters glycolipid metabolism. C2 Adamantanyl glucosylceramide (d18:1/2:0) can be used for the research of Gaucher disease and Fabry disease[1].

In Vitro

C2 Adamantanyl glucosylceramide (d18:1/2:0) (10-7500 μM; 20 min) inhibits the activity of recombinant glucocerebrosidase at pH 7 (at concentrations ≥5 μM), but exerts no effect at pH 5[1].
C2 Adamantanyl glucosylceramide (d18:1/2:0) (40 μM; 3 h) acts as a competitive inhibitor of lactosylceramide synthase in Vero cell microsomes, reduces endogenous LacCer synthesis, and generates an alternative product[1].
C2 Adamantanyl glucosylceramide (d18:1/2:0) (10-40 μM) increases the levels of all neutral glycosphingolipids in Vero cells at concentrations of 10 μM and 20 μM, whereas at 40 μM, it depletes all downstream GSL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C2 Adamantanyl glucosylceramide (d18:1/2:0) Related Antibodies

Immunofluorescence[1]

Cell Line: N370S Gaucher disease fibroblasts
Concentration: 40 μM
Incubation Time: 3 days
Result: Enhanced overall GCC fluorescence signal intensity.
Increased colocalization of GCC with lysosomal marker LAMP-1 (to levels indistinguishable from wild-type fibroblasts).
Partially reduced colocalization of GCC with ER marker PDI.
Increased GCC protein levels by ~2-fold (both immature and mature forms) in treated N370S fibroblasts compared to untreated cells.
Molecular Weight

635.87

Formula

C36H61NO8
SMILES

O[C@H]1[C@@H]([C@H](O[C@H]([C@@H]1O)OC[C@@H]([C@@H](/C=C/CC/C=C/CCCCCCCCC)O)NC(CC23C[C@@H]4C[C@@H](C[C@H](C3)C4)C2)=O)CO)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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C2 Adamantanyl glucosylceramide (d18:1/2:0) Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C2 Adamantanyl glucosylceramide (d18:1/2:0)Adamantanyl GluCer (d18:1/2:0) Adamantanyl glucosylceramide (d18:1/2:0) AdaGluCer (d18:1/2:0)Glycosidasecomplex glycosphingolipidsfibroblastslactosylceramideglucocerebrosidaseVero cellslysosomesglucosylceramideendoplasmic reticulumGaucher diseaselactosylceramide synthaseInhibitorinhibitorinhibit

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