2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. Centanamycin

Centanamycin (ML-970; AS-I-145; NSC 716970) is a novel DNA-binding agent, and shows cytotoxic activity, with an average GI50 of 34 nM in NCI-60 cell line screening.

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Centanamycin

Centanamycin Chemical Structure

CAS No. : 413577-16-9

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Centanamycin Related Antibodies

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Description

Centanamycin (ML-970; AS-I-145; NSC 716970) is a novel DNA-binding agent, and shows cytotoxic activity, with an average GI50 of 34 nM in NCI-60 cell line screening[1].

Cellular Effect
Cell Line Type Value Description References
K562 IC50
0.045 μM
Compound: 11a
The concentration required for inhibiting the growth of the human K562 chronic myeloid leukemia cells by 50%
The concentration required for inhibiting the growth of the human K562 chronic myeloid leukemia cells by 50%
[PMID: 15916443]
L1210 IC50
0.18 μM
Compound: 11a
The concentration required for inhibiting the growth of the murine L1210 leukemia cells by 50%
The concentration required for inhibiting the growth of the murine L1210 leukemia cells by 50%
[PMID: 15916443]
L1210 IC50
55 nM
Compound: 6
Cytotoxicity against mouse L1210 cells after 3 days by MTT assay
Cytotoxicity against mouse L1210 cells after 3 days by MTT assay
[PMID: 20579889]
P815 IC50
0.068 μM
Compound: 11a
The concentration required for inhibiting the growth of the murine P815 mastocytoma cells by 50%
The concentration required for inhibiting the growth of the murine P815 mastocytoma cells by 50%
[PMID: 15916443]
P815 IC50
0.068 μM
Compound: 4, CBI-TMI
Cytotoxicity against mouse P815 cells after 3 days
Cytotoxicity against mouse P815 cells after 3 days
[PMID: 16919946]
Masse moléculaire

453.92

Formule

C24H24ClN3O4
CAS No.
SMILES

O=C(C1=CC2=C(N1)C(OC)=C(OC)C(OC)=C2)NC3=C(CCCl)C4=C(C=CC=C4)C(N)=C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
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Centanamycin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Centanamycin413577-16-9ML-970 AS-I-145 NSC 716970ML970ML 970NSC716970NSC 716970NSC-716970Nucleoside Antimetabolite/AnalogNCI-60DNA-binding agentcell cytotoxicInhibitorinhibitorinhibit

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