2. Membrane Transporter/Ion Channel
  3. CFTR
  4. CFTR potentiator 1

CFTR potentiator 1 (I1421) is a potent CFTR potentiator with an EC50 value of 64 nM. CFTR potentiator 1 allosterically activates a wide range of CF-causing mutants, such as ΔF508 and G551D CFTR.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CFTR potentiator 1

CFTR potentiator 1 構造式

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CFTR potentiator 1 関連抗体

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製品説明

CFTR potentiator 1 (I1421) is a potent CFTR potentiator with an EC50 value of 64 nM. CFTR potentiator 1 allosterically activates a wide range of CF-causing mutants, such as ΔF508 and G551D CFTR[1].

体内実験

Pharmacokinetic Parameters of CFTR potentiator 1 (I1421) in Male C57BL/6 mice[1].
1.19

Route Dose (mg/kg) Tmax (h) Cmax (ng/mL) AUClast (h*ng/mL) T1/2 (h) CL (ml/min/kg) Vss (1/kg) %F
IP 10 0.25 2617 2145 2.16 - - -
PO 10 0.25 1181 1211 1.24 - - 60
SC 10 0.50 625 1512 1.36 - - -
IV 3 - 2354 610 1.78 81.51 2.49 -

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

338.36

分子式

C18H18N4O3
SMILES

NC1=NN(C([C@@H](COC2=CC=CC=C2)C)=O)C3=CC(C(N)=O)=CC=C31
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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CFTR potentiator 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CFTR potentiator 1CFTR potentiator1CFTR potentiator-1CFTRCystic fibrosis transmembrane conductance regulatorCFTR potentiatorΔF508 and G551D CFTRInhibitorinhibitorinhibit

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CFTR potentiator 1
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HY-161753
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