Chitinase, Serratia marcescens  (Synonyms: AMCase, Serratia marcescens)

Chitinase, Serratia marcescens is a chitinase from Serratia marcescens. Chitinase is a chitin-targeting enzyme with chitin hydrolysis activity. Chitinase inhibits chitin-induced innate type 2 inflammation in the lung. Chitinase augments chitin-free, allergen-induced Th2 inflammation. Chitinase mediates effector functions of IL-13^[1].

Chitinase can be used in the research of pathogenesis of various human fibrotic and inflammatory disorders, particularly those of the lung (idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, sarcoidosis, and asthma) and the gastrointestinal tract (inflammatory bowel diseases (IBDs) and colon cancer)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

9001-06-3

Solid

Light yellow to light brown

[Chitinase, serratia marcescens]

3.2.1.14

≥200 U/g soild

One unit is defined as the amount of enzyme that will liberate 1.0 mg of N-acetyl-D-glucosamine from chitin per hour at pH 6.0 at 25°C in a 2 hour assay

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lee CG, et al. Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury. Annu Rev Physiol. 2011;73:479-501.  [Content Brief]