2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Clobutinol

Clobutinol is a compound that has anti-tussive effects. Clobutinol affects heart rate and blood pressure, it can be used for cough related research.

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Clobutinol

Clobutinol Estructura química

No. CAS : 14860-49-2

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Clobutinol Related Antibodies

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Descripciòn

Clobutinol is a compound that has anti-tussive effects. Clobutinol affects heart rate and blood pressure, it can be used for cough related research[1][2][3].

In Vitro

Clobutinol (10 μM) significantly inhibits the voltage-gated outward current in hERG-expressing cells[1].
Clobutinol (0-1000 μM) inhibits the outward current in hERG transfected cells with an IC50 value of 1.9 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clobutinol Related Antibodies
In Vivo

Clobutinol (1-20 mg/kg; i.v. once) has no obvious effect on the airway of guinea-pigs[2].
Clobutinol (1 and 10 mg/kg; i.v. once) affects heart rate and mean blood pressure of guinea pigs[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Anaesthetized guinea-pigs[2]
Dosage: 1-20 mg/kg
Administration: Intravenous injection; 1-20 mg/kg once
Result: Showed no obvious effect on the airways, but affected the cardiovascular system considerably with a high dose.
Animal Model: Anesthetized closed-chest guinea pigs[3]
Dosage: 1 and 10 mg/kg
Administration: Intravenous injection; 1 and 10 mg/kg once
Result: Decreased the heart rate with a dose of 1 mg/kg, and decreased the heart rate and mean blood pressure with a dose of 10 mg/kg.
Peso molecular

255.78

Fòrmula

C14H22ClNO
No. CAS
SMILES

ClC1=CC=C(CC(C)(C(CN(C)C)C)O)C=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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Clobutinol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Clobutinol14860-49-2Potassium ChannelKcsAanti-tussivecoughheart rateblood pressurehERGguinea pigInhibitorinhibitorinhibit

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Nombre del producto:
Clobutinol
Cat. No.:
HY-148144
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