14860-49-2
14860-49-2
Chemical Structure
Clobutinol
- No. CAS: 14860-49-2
- Formula:C14H22ClNO
- Molecular Weight:255.78
IUPAC Name: 1-(4-chlorophenyl)-4-(dimethylamino)-2,3-dimethylbutan-2-ol
InChIKey: KVHHQGIIZCJATJ-UHFFFAOYSA-N
SMILES: ClC1=CC=C(CC(C)(C(CN(C)C)C)O)C=C1
Biological Activity: Clobutinol is a compound that has anti-tussive effects. Clobutinol affects heart rate and blood pressure, it can be used for cough related research[1][2][3].
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Clobutinol | Clobutinol is a compound that has anti-tussive effects. Clobutinol affects heart rate and blood pressure, it can be used for cough related research. | |||||||||||||||||||||
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References
- [1]. Deisemann H, et al. Effects of common antitussive drugs on the hERG potassium channel current. J Cardiovasc Pharmacol. 2008 Dec;52(6):494-9. [Content Brief]
- [2]. Salonen RO. Comparison of the effects of two opioid antitussives, vadocaine hydrochloride, clobutinol and lidocaine on lung mechanics in guinea-pigs. Arzneimittelforschung. 1988 Apr;38(4A):609-12. [Content Brief]
- [3]. Takahara A, Set al. Clobutinol delays ventricular repolarization in the guinea pig heart: comparison with cardiac effects of HERG K+ channel inhibitor E-4031. J Cardiovasc Pharmacol. 2009 Dec;54(6):552-9. [Content Brief]
