2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Clobutinol

Clobutinol is a compound that has anti-tussive effects. Clobutinol affects heart rate and blood pressure, it can be used for cough related research.

For research use only. We do not sell to patients.

Clobutinol Chemical Structure

Clobutinol Chemical Structure

CAS No. : 14860-49-2

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Clobutinol Related Antibodies

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Description

Clobutinol is a compound that has anti-tussive effects. Clobutinol affects heart rate and blood pressure, it can be used for cough related research[1][2][3].

In Vitro

Clobutinol (10 μM) significantly inhibits the voltage-gated outward current in hERG-expressing cells[1].
Clobutinol (0-1000 μM) inhibits the outward current in hERG transfected cells with an IC50 value of 1.9 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clobutinol Related Antibodies
In Vivo

Clobutinol (1-20 mg/kg; i.v. once) has no obvious effect on the airway of guinea-pigs[2].
Clobutinol (1 and 10 mg/kg; i.v. once) affects heart rate and mean blood pressure of guinea pigs[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Anaesthetized guinea-pigs[2]
Dosage: 1-20 mg/kg
Administration: Intravenous injection; 1-20 mg/kg once
Result: Showed no obvious effect on the airways, but affected the cardiovascular system considerably with a high dose.
Animal Model: Anesthetized closed-chest guinea pigs[3]
Dosage: 1 and 10 mg/kg
Administration: Intravenous injection; 1 and 10 mg/kg once
Result: Decreased the heart rate with a dose of 1 mg/kg, and decreased the heart rate and mean blood pressure with a dose of 10 mg/kg.
Molecular Weight

255.78

Formula

C14H22ClNO
CAS No.
SMILES

ClC1=CC=C(CC(C)(C(CN(C)C)C)O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Clobutinol Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Clobutinol14860-49-2Potassium ChannelKcsAanti-tussivecoughheart rateblood pressurehERGguinea pigInhibitorinhibitorinhibit

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