Copovidone  (Synonyms: ポリ(1-ビニルピロリドン-co-酢酸ビニル))

Copovidone can be used as an excipient, such as Film formers, adhesives, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs^[1].

Copovidone (50% in ethanol) is a synthetic copolymer composed of vinyl pyrrolidone (VP) and vinyl acetate (VA)^[2].
Copovidone (50% in ethanol) can be used as a binder in the pharmaceutical field, especially in dry granulation and direct compression processes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(C₆H₉NO.C₄H₆O₂)_n

25086-89-9

Liquid

Colorless to light yellow

C=CN1C(CCC1)=O.CC(OC=C)=O.[n]

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  [Content Brief]

  [2]. Moroni A. A novel copovidone binder for dry granulation and direct-compression tableting[J]. Pharmaceutical Technology, 2001, 25(9; SUPP): 8-13.