DL-Fluorocitric acid barium
Based on 1 Customer Validation
DL-Fluorocitric acid barium is a glial cell metabolic inhibitor. DL-Fluorocitric acid barium inhibits mechanical hyperalgesia induced by subcutaneous injection of complete Freund's adjuvant in rats. DL-Fluorocitric acid barium inhibits nociceptive behaviors induced by Histamine (HY-B1204) in mice and blocks the phosphorylation of the NMDA receptor NR1 subunit in the lumbar spinal cord of mice. DL-Fluorocitric acid (barium) can be used in the research of mechanical hyperalgesia and nociceptive pain.
For research use only. We do not sell to patients.
- CAS No.: 100929-81-5
- Formula: C6H7FO7.3/2Ba
- Molecular Weight:416.10
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
DL-Fluorocitric acid barium (10-40 pmol; intrathecal injection; single administration) dose-dependently inhibits histamine (HY-B1204)-induced nociceptive behaviors in mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (adult male, 190-220 g, inflammatory pain induced by subcutaneous CFA injection into left hind-paw)[1]
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Dosage:0.01 nmol; 0.1 nmol; 1 nmol; 0.01 nmol (co-administered with 1 nmol LY341495)
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Administration:i.t.; single dose; 10 min pre-CFA
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Result:Increased paw withdrawal mechanical threshold to 9.50 g at 0.01 nmol.
Increased paw withdrawal mechanical threshold to 16.00 g at 0.1 nmol.
Increased paw withdrawal mechanical threshold to 54.33 g at 1 nmol.
Increased paw withdrawal mechanical threshold to 44.2 g at 0.01 nmol co-administered with 1 nmol LY341495 (HY-70059), with a percentage maximal effect (%MPE) of 89.23%.
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Animal Model:ddY (male, 22-25 g)[2]
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Dosage:10 pmol; 20 pmol; 40 pmol
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Administration:i.t.; 1 hour before histamine administration
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Result:Dose-dependently suppressed histamine-induced nociceptive behaviors.
Completely eliminated histamine-induced nociceptive behaviors at 40 pmol dose.
Significantly suppressed the histamine-induced increase in phosphorylated NR1 subunits of NMDA receptors in the dorsal lumbar spinal cord (P < 0.01) at 40 pmol dose.
Chemical Information
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CAS No. 100929-81-5
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Appearance Solid
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Molecular Weight 416.10
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Formula C6H7FO7.3/2Ba
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Color White to off-white
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SMILES
OC(CC(O)=O)(C(O)=O)C(F)C(O)=O.[1.5].[Ba]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (274 KB)
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SDS (642 KB)
- English - EN (642 KB)
- Français - FR (642 KB)
- Deutsch - DE (642 KB)
- Norwegian - NO (642 KB)
- Español - ES (642 KB)
- Swedish - SV (642 KB)
- Italian - IT (642 KB)
- Korean - KR (642 KB)
- Portuguese - PT (642 KB)
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Handling Instructions (2659 KB)
References
[1]. Zhang T, et al. Antinociceptive synergistic effect of spinal mGluR2/3 antagonist and glial cells inhibitor on peripheral inflammation-induced mechanical hypersensitivity. Brain Res Bull. 2009;79(3-4):219-223. [Content Brief]
[2]. Mizoguchi H, et al. Involvement of glial cells in the nociceptive behaviors induced by a high-dose of histamine administered intrathecally. Eur J Pharmacol. 2011;653(1-3):21-25. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DL-Fluorocitric acid barium Related Classifications
HY-W021450A Related Classifications
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