DRP1i27 dihydrochloride

Name: DRP1i27 dihydrochloride
Brand: MedChemExpress
SKU: HY-152086A
Rating: 4.5 (0 reviews)

製品番号: HY-152086A 純度: 98.63%: Data Sheet SDS COA 取扱説明書
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DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 dihydrochloride binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 dihydrochloride targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury.

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DRP1i27 dihydrochloride 構造式

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 616	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 616	在庫あり	Estimated Time of Arrival: December 31
Solid
1 mg	$190	在庫あり	Estimated Time of Arrival: December 31
5 mg	$560	在庫あり	Estimated Time of Arrival: December 31
10 mg	$900	在庫あり	Estimated Time of Arrival: December 31
25 mg	$1900	在庫あり	Estimated Time of Arrival: December 31
50 mg	$3050	在庫あり	Estimated Time of Arrival: December 31
100 mg	$4800	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Other Forms of DRP1i27 dihydrochloride:

DRP1i27 在庫あり

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純度とドキュメンテーション
参考文献
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製品説明

体外実験

DRP1i27 (0-50 μM) dihydrochloride directly binds to and inhibits GTPase activity of human Drp1^[1].
DRP1i27 (0-50 μM) dihydrochloride is able to increase cellular networks of mitochondria in human and mouse fibroblasts in a Drp1-dependent manner^[1].
DRP1i27 dihydrochloride has a binding affinity of 286 μM in the SPR assay and a K_D value of 190 μM via the MST assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

439.38

分子式

C₂₀H₂₈Cl₂N₆O

Appearance

Solid

Color

Light yellow to brown

SMILES

[H]Cl.CC1=C(NC=N1)CN2C[C@@H]3CC[C@@H](N(C3)CC4=CC=C(O4)C5=NNC=C5)C2.[H]Cl

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶剤 & 溶解度

体外:

DMSO : 50 mg/mL (113.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2759 mL	11.3797 mL	22.7593 mL
5 mM	0.4552 mL	2.2759 mL	4.5519 mL
10 mM	0.2276 mL	1.1380 mL	2.2759 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.63%

Select Batch:

データシート (271 KB) SDS (252 KB)

COA (250 KB) HNMR (265 KB) RP-HPLC (247 KB) MS (159 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Rosdah AA, et al. A novel small molecule inhibitor of human Drp1. Sci Rep. 2022 Dec 13;12(1):21531. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2759 mL	11.3797 mL	22.7593 mL	56.8984 mL
	5 mM	0.4552 mL	2.2759 mL	4.5519 mL	11.3797 mL
	10 mM	0.2276 mL	1.1380 mL	2.2759 mL	5.6898 mL
	15 mM	0.1517 mL	0.7586 mL	1.5173 mL	3.7932 mL
	20 mM	0.1138 mL	0.5690 mL	1.1380 mL	2.8449 mL
	25 mM	0.0910 mL	0.4552 mL	0.9104 mL	2.2759 mL
	30 mM	0.0759 mL	0.3793 mL	0.7586 mL	1.8966 mL
	40 mM	0.0569 mL	0.2845 mL	0.5690 mL	1.4225 mL
	50 mM	0.0455 mL	0.2276 mL	0.4552 mL	1.1380 mL
	60 mM	0.0379 mL	0.1897 mL	0.3793 mL	0.9483 mL
	80 mM	0.0284 mL	0.1422 mL	0.2845 mL	0.7112 mL
	100 mM	0.0228 mL	0.1138 mL	0.2276 mL	0.5690 mL