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  4. DSG Crosslinker

DSG Crosslinker  (Synonyms: Disuccinimidyl glutarate)

Art. -Nr.: HY-114697 Reinheit: 98.0%
COA
SDS
Handling Instructions Technical Support

DSG Crosslinker is an amine-reactive and noncleavable protein crosslinker. DSG Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

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CAS. Nr. : 79642-50-5

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Based on 4 publication(s) in Google Scholar

Other Forms of DSG Crosslinker:

DSG Crosslinker Related Antibodies

Top Publications Citing Use of Products

    DSG Crosslinker purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 23:e08902.  [Abstract]

    DSG Crosslinker (0-400 μM; 10 min). Crosslinking of 3×FLAG‐TDP‐43 in 293T cells with increasing concentrations of DSG shows an increase in the dimeric form and a decrease in the monomeric form. GAPDH was used as the loading control.

    DSG Crosslinker purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 23:e08902.  [Abstract]

    DSG Crosslinker (100 μM; 10 min). Overexpression of 3×FLAG‐TDP‐43, 3×FLAG‐NLS‐FokI, 3×FLAG‐NLS‐FokT, and 3×FLAG‐NLS‐FokTN6A plasmids in 293T cells followed by crosslinking with 100 µM DSG. Western blot analysis was performed to examine their dimerization.

    • Biologische Aktivität

    • Reinheit & Dokumentation

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    Beschreibung

    DSG Crosslinker is an amine-reactive and noncleavable protein crosslinker. DSG Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

    Molekulargewicht

    326.26

    Formel

    C13H14N2O8
    CAS. Nr.
    Appearance

    Solid

    Color

    Off-white to gray

    SMILES

    O=C(CCCC(ON1C(CCC1=O)=O)=O)ON2C(CCC2=O)=O
    Versand

    Room temperature in continental US; may vary elsewhere.
    Speicherung
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Lösungsmittel & Löslichkeit
    In Vitro: 

    DMSO : 100 mg/mL (306.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.0650 mL 15.3252 mL 30.6504 mL
    5 mM 0.6130 mL 3.0650 mL 6.1301 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molaritätsrechner

    • Verdünnungsrechner

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Reinheit & Dokumentation

    Purity: 98.0%

    SDS (394 KB)

    COA (249 KB) HNMR (139 KB) MS (198 KB)

    Handling Instructions (2659 KB)

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.0650 mL 15.3252 mL 30.6504 mL 76.6260 mL
    5 mM 0.6130 mL 3.0650 mL 6.1301 mL 15.3252 mL
    10 mM 0.3065 mL 1.5325 mL 3.0650 mL 7.6626 mL
    15 mM 0.2043 mL 1.0217 mL 2.0434 mL 5.1084 mL
    20 mM 0.1533 mL 0.7663 mL 1.5325 mL 3.8313 mL
    25 mM 0.1226 mL 0.6130 mL 1.2260 mL 3.0650 mL
    30 mM 0.1022 mL 0.5108 mL 1.0217 mL 2.5542 mL
    40 mM 0.0766 mL 0.3831 mL 0.7663 mL 1.9157 mL
    50 mM 0.0613 mL 0.3065 mL 0.6130 mL 1.5325 mL
    60 mM 0.0511 mL 0.2554 mL 0.5108 mL 1.2771 mL
    80 mM 0.0383 mL 0.1916 mL 0.3831 mL 0.9578 mL
    100 mM 0.0307 mL 0.1533 mL 0.3065 mL 0.7663 mL
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    DSG Crosslinker Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    DSG Crosslinker79642-50-5Disuccinimidyl glutarateBiochemical Assay ReagentscleavableADClinkerInhibitorinhibitorinhibit

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