2. Immunology/Inflammation
  3. FAP
  4. Rofapitide tetraxetan

Rofapitide tetraxetan  (Synonyms: FAP-2286)

製品番号: HY-147057 純度: 99.54%
COA 取扱説明書 Technical Support

Rofapitide tetraxetan (FAP-2286) is a potent and selective FAP-binding peptide with a mean IC50 value of 2.7 nM for binding to FAP. Rofapitide tetraxetan can be labeled with radionuclides for diagnostic applications. Rofapitide tetraxetan has antitumor activity.

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CAS 番号 : 2581741-18-4

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 4206 在庫あり
Solution
10 mM * 1 mL in DMSO USD 4206 在庫あり
Solid
1 mg $720 在庫あり
5 mg $1600 在庫あり
10 mg $2600 在庫あり
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100 mg   お問い合わせ  

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カスタマーレビュー

Based on 7 publication(s) in Google Scholar

Other Forms of Rofapitide tetraxetan:

Rofapitide tetraxetan 関連抗体

Top Publications Citing Use of Products

    Rofapitide tetraxetan purchased from MedChemExpress. Usage Cited in: Sci Rep. 2025 Mar 3;15(1):7475.  [Abstract]

    Binding percentage of [13xLa]La-FAPI-2286 using HEK FAP+, and MCF7 and CHO FAP-cells.

    Rofapitide tetraxetan purchased from MedChemExpress. Usage Cited in: Sci Rep. 2025 Mar 3;15(1):7475.  [Abstract]

    Percentage of internalized [13xLa]La-FAPI-2286 to HEK cells overexpressed FAP receptors, and CHO cells, control cells, as a function of time.

    Rofapitide tetraxetan purchased from MedChemExpress. Usage Cited in: Sci Rep. 2025 Mar 3;15(1):7475.  [Abstract]

    The %ID/g of the normal mice up to 48 h post-injection of [13xLa]La-FAPI-2286. All values were presented as mean ± standard deviation (P value < 0.05).

    Rofapitide tetraxetan purchased from MedChemExpress. Usage Cited in: Pharmaceuticals (Basel). 2024 Aug 29;17(9):1141.

    MIP and hybrid PET/CT scan slice from December 2023 using [68Ga]Ga-FAP-2286 (Rofapitide tetraxetan): the red arrow marks an intense focal tracer uptake, which has been interpreted as the primary tumor lesion atop the confluence of the right and left hepatic bile ducts (Klatskin tumor). SUVmax 13.7; SUVpeak 10.7.

    Rofapitide tetraxetan purchased from MedChemExpress. Usage Cited in: Pharmaceuticals (Basel). 2024 Aug 29;17(9):1141.

    MIP and hybrid PET/CT scan slice from March 2024 using [68Ga]Ga-FAP-2286 (Rofapitide tetraxetan): the red arrow marks the primary tumor lesion with an increasing size and tracer uptake at this time point after chemotherapy with cisplatin, gemcitabine, and durvalumab. SUVmax 24.6; SUVpeak 20.5.

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    製品説明

    Rofapitide tetraxetan (FAP-2286) is a potent and selective FAP-binding peptide with a mean IC50 value of 2.7 nM for binding to FAP. Rofapitide tetraxetan can be labeled with radionuclides for diagnostic applications. Rofapitide tetraxetan has antitumor activity[1].

    体外実験

    Rofapitide tetraxetan (0.1-30 nM, 1 h) reduces fuorophore-labeled competitor peptide bound to cells in human WI-38 fibroblast like fetal lung cell line[1].
    Rofapitide tetraxetan (5 nM, 1, 3, 8, 24, and 72 h) maintains long tumor retention and suppression in HEK-FAP cells[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Rofapitide tetraxetan 関連抗体
    体内実験

    Rofapitide tetraxetan (30 MBq/nmol for intravenous injection) accumulated atably maintained in the tumors of HEK-FAP tumor-bearing mice[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: HEK-FAP tumor-bearing mice[1]
    Dosage: 30 MBq/nmol
    Administration: Intravenous injection (i.v.)
    Result: Increased tumor-to-kidney (T/K) ratio with the highest differential uptake of 7.5 T/K obtained at 48 h post injection.
    Maintained accumulation at 3 h after injection with 10.8 ID/g.
    分子量

    1470.77

    分子式

    C67H99N13O18S3
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(N1[C@@](C(N[C@@](C(N[C@H](C(N[C@H](C2=O)CC3=CC=CC=C3)=O)CCC(N)=O)=O)([H])[C@H](O)C)=O)([H])CCC1)[C@@](CCC4)([H])N4C([C@H](CSCC5=CC(CSCCNC(CN(CCN(CC6)CC(O)=O)CCN(CCN6CC(O)=O)CC(O)=O)=O)=CC(CSC[C@H](N2)C(O)=O)=C5)NC(CCCCC)=O)=O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    -20°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
    溶剤 & 溶解度
    体外: 

    H2O : ≥ 100 mg/mL (67.99 mM)

    DMSO : ≥ 50 mg/mL (34.00 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.6799 mL 3.3996 mL 6.7992 mL
    5 mM 0.1360 mL 0.6799 mL 1.3598 mL
    10 mM 0.0680 mL 0.3400 mL 0.6799 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

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    体内:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL (34.00 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.54%

    COA (255 KB) LCMS (87 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 0.6799 mL 3.3996 mL 6.7992 mL 16.9979 mL
    5 mM 0.1360 mL 0.6799 mL 1.3598 mL 3.3996 mL
    10 mM 0.0680 mL 0.3400 mL 0.6799 mL 1.6998 mL
    15 mM 0.0453 mL 0.2266 mL 0.4533 mL 1.1332 mL
    20 mM 0.0340 mL 0.1700 mL 0.3400 mL 0.8499 mL
    25 mM 0.0272 mL 0.1360 mL 0.2720 mL 0.6799 mL
    30 mM 0.0227 mL 0.1133 mL 0.2266 mL 0.5666 mL
    H2O 40 mM 0.0170 mL 0.0850 mL 0.1700 mL 0.4249 mL
    50 mM 0.0136 mL 0.0680 mL 0.1360 mL 0.3400 mL
    60 mM 0.0113 mL 0.0567 mL 0.1133 mL 0.2833 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Rofapitide tetraxetan Related Classifications

    • Molarity Calculator

    • Dilution Calculator

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Rofapitide tetraxetan2581741-18-4FAP-2286FAP2286FAP 2286FAPFibroblast activation proteintheranostictumorpepetide-targetedradionuclides therapyInhibitorinhibitorinhibit

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    製品名:
    Rofapitide tetraxetan
    製品番号:
    HY-147057
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