Fengabine  (Synonyms: SL 79229)

Fengabine is a GABAergic antidepressant agent. Fengabine can be used for the research of depression^[1].

Fengabine (50 mg/kg; i.p.; 2 days) prevents completely the learned helplessness induced by the unavoidable shock^[1].
Fengabine (150 mg/kg; i.p) decreases the percentage of time spent. Fengabine (25~50 mg/kg; i.p.) reverses the deficit in learning the step-down avoidance task^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

322.23

C₁₇H₁₇Cl₂NO

80018-06-0

OC1=CC=C(C=C1/C(C2=CC=CC=C2Cl)=N\CCCC)Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ascalone V, et al. Determination of the GABAergic antidepressant drug fengabine and some of its metabolites in plasma by capillary gas chromatography with electron-capture detection. J Chromatogr. 1989;490(1):81-90.  [Content Brief]

  [2]. Lloyd KG, et al. Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile. J Pharmacol Exp Ther. 1987;241(1):245-250.  [Content Brief]