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  4. GalNAc-L96

GalNAc-L96, a triantennary N-acetylgalactosamine (GalNAc), is a ligand of asialoglycoprotein receptor (ASGPR). GalNAc-L96 can be used to synthesize GalNAc-siRNA and can be used for oligonucleotide delivery.

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GalNAc-L96

GalNAc-L96 構造式

CAS 番号 : 1159408-62-4

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 487 在庫あり
Solution
10 mM * 1 mL in DMSO USD 487 在庫あり
Solid
5 mg $100 在庫あり
10 mg $170 在庫あり
25 mg $320 在庫あり
50 mg $450 在庫あり
100 mg $720 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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GalNAc-L96 関連抗体

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製品説明

GalNAc-L96, a triantennary N-acetylgalactosamine (GalNAc), is a ligand of asialoglycoprotein receptor (ASGPR). GalNAc-L96 can be used to synthesize GalNAc-siRNA and can be used for oligonucleotide delivery[1].

体外実験

The oligonucleotide H12 (A-PO-HCV-L96) carrying the triantennary GalNAc binds to asialoglycoprotein receptors (ASGPR), with a Ki of 10.4 nM[1].
The RNA carrying a triantennary GalNAc ligand R1 (sense-L96) binds to asialoglycoprotein receptors (ASGPR), with a Ki of 8.8 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GalNAc-L96 関連抗体
分子量

2608.95

分子式

C127H194N12O45
CAS 番号
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(CCCCCCCCCCC(N1[C@H](COC(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)C[C@@H](OC(CCC(O)=O)=O)C1)=O)NC(COCCC(NCCCNC(CCCCO[C@H]5[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O5)=O)=O)(COCCC(NCCCNC(CCCCO[C@H]6[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O6)=O)=O)COCCC(NCCCNC(CCCCO[C@H]7[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O7)=O)=O.CCN(CC)CC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

DMSO : 125 mg/mL (47.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3833 mL 1.9165 mL 3.8330 mL
5 mM 0.0767 mL 0.3833 mL 0.7666 mL
10 mM 0.0383 mL 0.1916 mL 0.3833 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.3833 mL 1.9165 mL 3.8330 mL 9.5824 mL
5 mM 0.0767 mL 0.3833 mL 0.7666 mL 1.9165 mL
10 mM 0.0383 mL 0.1916 mL 0.3833 mL 0.9582 mL
15 mM 0.0256 mL 0.1278 mL 0.2555 mL 0.6388 mL
20 mM 0.0192 mL 0.0958 mL 0.1916 mL 0.4791 mL
25 mM 0.0153 mL 0.0767 mL 0.1533 mL 0.3833 mL
30 mM 0.0128 mL 0.0639 mL 0.1278 mL 0.3194 mL
40 mM 0.0096 mL 0.0479 mL 0.0958 mL 0.2396 mL
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GalNAc-L96 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GalNAc-L961159408-62-4Drug IntermediateDrug IintermediateInhibitorinhibitorinhibit

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製品名:
GalNAc-L96
製品番号:
HY-147012
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