GalNAc-L96 free base
GalNAc-L96 free base is a conjugate of GalNAc and its ligand L96. When conjugated with the A-rich HCV sequence (H12), GalNAc-L96 free base binds potently to ASGPR, with a Ki value of 10.4 nM. GalNAc-L96 free base promotes siRNA delivery to hepatocytes.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1159408-61-3
- 分子式: C121H179N11O45
- 分子量:2507.76
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Other In-stock Forms of GalNAc-L96 free base
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Humanized PCSK9 mice[1]
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Dosage:6 mg/kg
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Administration:s.c.; single dose
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Result:Reduced serum PCSK9 protein levels to ~10.2% of baseline at day 14 post-dose.
Reduced hepatic PCSK9 mRNA levels to ~19.9% of baseline at day 14 post-dose.
化学情報
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CAS 番号 1159408-61-3
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分子量 2507.76
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分子式 C121H179N11O45
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SMILES
CC(N[C@H]([C@H]([C@H]([C@H](O1)COC(C)=O)OC(C)=O)OC(C)=O)[C@@H]1OCCCCC(NCCCNC(CCOCC(COCCC(NCCCNC(CCCCO[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)COC(C)=O)OC(C)=O)OC(C)=O)NC(C)=O)=O)=O)(COCCC(NCCCNC(CCCCO[C@H]3[C@@H]([C@H]([C@H]([C@H](O3)COC(C)=O)OC(C)=O)OC(C)=O)NC(C)=O)=O)=O)NC(CCCCCCCCCCC(N(C[C@@H](C4)OC(CCC(O)=O)=O)[C@@H]4COC(C5=CC=C(C=C5)OC)(C6=CC=CC=C6)C7=CC=C(C=C7)OC)=O)=O)=O)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Pradeep SP, et al. Enhanced liver-targeted delivery with ribofuranose-based GalNAc conjugates. Mol Ther Nucleic Acids. 2026;37(1):102871. Published 2026 Mar 4. [Content Brief]
[2]. Clua A, et al. Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes. Molecules. 2022;27(12):3944. Published 2022 Jun 20. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
GalNAc-L96 free base 関連分類
HY-153184 関連分類
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Keywords
- GalNAc-L96
- 1159408-61-3
- Asialoglycoprotein Receptor (ASGPR)
- Small Interfering RNA (siRNA)
- Asialoglycoprotein Receptor
- Ashwell-Morell Receptor
- hepatocyte
- PCSK9
- hepatocyte receptors
- primary mouse hepatocytes
- siRNA
- BALB/c mice
- asialoglycoprotein receptor
- Sprague-Dawley rats
- humanized PCSK9 mice
- receptor-mediated endocytosis
- Inhibitor
- inhibitor
- inhibit