GalNAc-L96
Based on 1 Customer Validation
GalNAc-L96, a triantennary N-acetylgalactosamine (GalNAc), is a ligand of asialoglycoprotein receptor (ASGPR). GalNAc-L96 can be used to synthesize GalNAc-siRNA and can be used for oligonucleotide delivery.
For research use only. We do not sell to patients.
- Purity: 97.0%
- CAS No.: 1159408-62-4
- Formula: C127H194N12O45
- Molecular Weight:2608.95
-
Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
The oligonucleotide H12 (A-PO-HCV-L96) carrying the triantennary GalNAc binds to asialoglycoprotein receptors (ASGPR), with a Ki of 10.4 nM[1].
The RNA carrying a triantennary GalNAc ligand R1 (sense-L96) binds to asialoglycoprotein receptors (ASGPR), with a Ki of 8.8 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1159408-62-4
-
Appearance Solid
-
Molecular Weight 2608.95
-
Formula C127H194N12O45
-
Color Off-white to light yellow
-
SMILES
O=C(CCCCCCCCCCC(N1[C@H](COC(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)C[C@@H](OC(CCC(O)=O)=O)C1)=O)NC(COCCC(NCCCNC(CCCCO[C@H]5[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O5)=O)=O)(COCCC(NCCCNC(CCCCO[C@H]6[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O6)=O)=O)COCCC(NCCCNC(CCCCO[C@H]7[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O7)=O)=O.CCN(CC)CC
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 125 mg/mL (47.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (276 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.3833 mL | 1.9165 mL | 3.8330 mL | 9.5824 mL |
| 5 mM | 0.0767 mL | 0.3833 mL | 0.7666 mL | 1.9165 mL | |
| 10 mM | 0.0383 mL | 0.1916 mL | 0.3833 mL | 0.9582 mL | |
| 15 mM | 0.0256 mL | 0.1278 mL | 0.2555 mL | 0.6388 mL | |
| 20 mM | 0.0192 mL | 0.0958 mL | 0.1916 mL | 0.4791 mL | |
| 25 mM | 0.0153 mL | 0.0767 mL | 0.1533 mL | 0.3833 mL | |
| 30 mM | 0.0128 mL | 0.0639 mL | 0.1278 mL | 0.3194 mL | |
| 40 mM | 0.0096 mL | 0.0479 mL | 0.0958 mL | 0.2396 mL |
GalNAc-L96 Related Classifications
HY-147012 Related Classifications
Powered by Bioz