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  3. Drug Intermediate
  4. GalNAc-L96

GalNAc-L96, a triantennary N-acetylgalactosamine (GalNAc), is a ligand of asialoglycoprotein receptor (ASGPR). GalNAc-L96 can be used to synthesize GalNAc-siRNA and can be used for oligonucleotide delivery.

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GalNAc-L96

GalNAc-L96 Chemische Struktur

CAS. Nr. : 1159408-62-4

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
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Solid
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Other Forms of GalNAc-L96:

GalNAc-L96 Related Antibodies

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Beschreibung

GalNAc-L96, a triantennary N-acetylgalactosamine (GalNAc), is a ligand of asialoglycoprotein receptor (ASGPR). GalNAc-L96 can be used to synthesize GalNAc-siRNA and can be used for oligonucleotide delivery[1].

In Vitro

The oligonucleotide H12 (A-PO-HCV-L96) carrying the triantennary GalNAc binds to asialoglycoprotein receptors (ASGPR), with a Ki of 10.4 nM[1].
The RNA carrying a triantennary GalNAc ligand R1 (sense-L96) binds to asialoglycoprotein receptors (ASGPR), with a Ki of 8.8 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GalNAc-L96 Related Antibodies
Molekulargewicht

2608.95

Formel

C127H194N12O45
CAS. Nr.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(CCCCCCCCCCC(N1[C@H](COC(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)C[C@@H](OC(CCC(O)=O)=O)C1)=O)NC(COCCC(NCCCNC(CCCCO[C@H]5[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O5)=O)=O)(COCCC(NCCCNC(CCCCO[C@H]6[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O6)=O)=O)COCCC(NCCCNC(CCCCO[C@H]7[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O7)=O)=O.CCN(CC)CC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 125 mg/mL (47.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3833 mL 1.9165 mL 3.8330 mL
5 mM 0.0767 mL 0.3833 mL 0.7666 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.3833 mL 1.9165 mL 3.8330 mL 9.5824 mL
5 mM 0.0767 mL 0.3833 mL 0.7666 mL 1.9165 mL
10 mM 0.0383 mL 0.1916 mL 0.3833 mL 0.9582 mL
15 mM 0.0256 mL 0.1278 mL 0.2555 mL 0.6388 mL
20 mM 0.0192 mL 0.0958 mL 0.1916 mL 0.4791 mL
25 mM 0.0153 mL 0.0767 mL 0.1533 mL 0.3833 mL
30 mM 0.0128 mL 0.0639 mL 0.1278 mL 0.3194 mL
40 mM 0.0096 mL 0.0479 mL 0.0958 mL 0.2396 mL
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GalNAc-L96 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GalNAc-L961159408-62-4Drug IntermediateDrug IintermediateInhibitorinhibitorinhibit

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