γ-2-MSH (41-58), amide

Art. -Nr.: HY-P1922 Reinheit: 98.16%: Data Sheet
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γ-2-MSH (41-58), amide is derived from γ-2-MSH. γ-2-MSH is a twelve amino acid peptide that is derived from the N-terminal fragment of proopiomelanocortin (POMC) and contains the His-Phe-Arg-Trp motif common to all melanocortin endogenous agonist ligands.

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Kundenspezifische Peptidsynthese

γ-2-MSH (41-58), amide Chemische Struktur

CAS. Nr. : 799841-81-9

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10 mg	Auf Lager	Estimated Time of Arrival: December 31
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Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Melanocortin Receptor Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

MC1R MC3R MC2R MC4R MC5R

Biologische Aktivität
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Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	1.2 1 Compound: 12	Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting method Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting method	[PMID: 29094944]
HEK293	IC₅₀	40 1 Compound: 12	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	[PMID: 29094944]
HEK293	IC₅₀	45 1 Compound: 12	Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK293 cells after 40 mins by gamma counting method Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK293 cells after 40 mins by gamma counting method	[PMID: 29094944]
HEK293	EC₅₀	65 1 Compound: 12	Agonist activity at human MC4R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins Agonist activity at human MC4R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	[PMID: 29094944]
HEK293	EC₅₀	70 1 Compound: 12	Agonist activity at human MC1R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation measured after 3 mins Agonist activity at human MC1R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation measured after 3 mins	[PMID: 29094944]
HEK293	EC₅₀	390 1 Compound: 12	Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	[PMID: 29094944]
HEK293	IC₅₀	330 1 Compound: 12	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method	[PMID: 29094944]
HEK293	EC₅₀	520 1 Compound: 12	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	[PMID: 29094944]
HEK293	EC₅₀	390 1 Compound: 12	Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	[PMID: 29094944]
HEK293	EC₅₀	65 1 Compound: 12	Agonist activity at human MC4R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins Agonist activity at human MC4R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	[PMID: 29094944]
HEK293	EC₅₀	520 1 Compound: 12	Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins Agonist activity at human MC3R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 mins	[PMID: 29094944]
HEK293	EC₅₀	70 1 Compound: 12	Agonist activity at human MC1R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation measured after 3 mins Agonist activity at human MC1R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation measured after 3 mins	[PMID: 29094944]
HEK293	IC₅₀	1.2 1 Compound: 12	Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting method Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by gamma counting method	[PMID: 29094944]
HEK293	IC₅₀	330 1 Compound: 12	Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK293 cells after 40 mins by gamma counting method	[PMID: 29094944]
HEK293	IC₅₀	40 1 Compound: 12	Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting method	[PMID: 29094944]
HEK293	IC₅₀	45 1 Compound: 12	Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK293 cells after 40 mins by gamma counting method Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK293 cells after 40 mins by gamma counting method	[PMID: 29094944]

Molekulargewicht

1569.79

Formel

C₇₄H₁₀₀N₂₂O₁₅S

CAS. Nr.

799841-81-9

Appearance

Solid

Color

White to off-white

Sequence Shortening

YVMGHFRWDRFG-NH2

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Reinheit & Dokumentation

Purity: 98.16%

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Data Sheet (258 KB) SDS (252 KB)

COA (248 KB) RP-HPLC (264 KB) MS (69 KB) Elemental Analysis Report (107 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Joseph CG, et al. γ₂-Melanocyte stimulation hormone (γ₂-MSH) truncation studies results in the cautionary note that γ₂-MSH is not selective for the mouse MC3R over the mouse MC5R. Peptides. 2010 Dec;31(12):2304-13. [Content Brief]