CKB - creatine kinase B Gene

Homo sapiens

Also known as BCK; B-CK; CKBB; CPK-B; HEL-211; HEL-S-29

Gene ID: 1152 | Gene type: protein coding

About CKB

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:103,519,667-103,522,830 (from NCBI)

This gene has 18 transcripts (splice variants), 214 orthologues and 4 paralogues. Broad expression in colon (RPKM 268.3), prostate (RPKM 227.9) and 18 other tissues.

Summary

The protein encoded by this gene is a cytoplasmic Enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008]

CKB Products(2)

mRNA	Protein	Name
NM_001362531.2	NP_001349460.1	creatine kinase B-type isoform 2
NM_001823.5	NP_001814.2	creatine kinase B-type isoform 1

CKB Protein Structure

ATP-gua_PtransN

ATP-gua_Ptrans

0
100
200
300
381 a.a.

Protein Preferred Names

Protein Names

creatine kinase B-type

brain creatine kinase

Recombinant CKB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7897	Creatine kinase B-type/CKB Protein, Human (His)	P12277 (M1-K381)	≥95%

Related Diseases

Diseases

Alias

Subendocardial Myocardial Infarction

Neonatal Hypoxic And Ischemic Brain Injury

Perinatal Asphyxia	Hypoxic-Ischemic Encephalopathy
Perinatal Hypoxia	Hie
Hypoxic And Ischemic Brain Injury In The Newborn	Encephalopathy, Hypoxic Ischemic
Encephalopathies Hypoxic-Ischemic	Hypoxic Ischemic Encephalopathy
Hypoxic Ischaemic Brain Injury	Brain Hypoxia
Cerebral Hypoxia	Hypoxic Encephalopathy
Hypoxic Brain Damage	Hypoxic Brain Injury
Brainstem Hypoxia	Hypoxic Brainstem Damage

Acute Myocardial Infarction

Cardiac Attack

Heart Attack

Cardiac Arrest

Cardiopulmonary Arrest	Circulatory Arrest
Heart Arrest

Bacterial Meningitis

Meningitis, Bacterial	Meningitis Bacterial
Bm - [Bacterial Meningitis]	Leptomeningitis Bacterial
Pachymeningitis Bacterial	Arachnoiditis Bacterial

Prostate Rhabdomyosarcoma

Rhabdomyosarcoma Of The Prostate

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Small Cell Cancer Of The Lung

Small Cell Lung Cancer	Small Cell Lung Carcinoma
Sclc	Small-Cell Cancer Of Lung
Lung Small Cell Carcinoma	Sclc1
Sccl	Cancer, Lung, Small Cell
Small Cell Carcinoma Of Lung	Carcinoma, Small Cell

Mitral Valve Insufficiency

Mitral Regurgitation	Congenital Insufficiency Of Mitral Valve
Congenital Mitral Insufficiency	Congenital Mitral Regurgitation
Mitral Valve Incompetence	Mitral Valve Regurgitation
Mr - [Mitral Regurgitation]	Mi - [Mitral Incompetence]
Mitral Valve Annular Incompetency	Congenital Mitral Valve Incompetence
Congenital Mitral Valve Insufficiency	Congenital Mitral Valve Regurgitation
Congenital Mitral Incompetence

Osteopetrosis

Marble Bone Disease	Albers-Schonberg Disease
Osteopetroses	Marble Bones
Osteopetrosis And Related Disorders	Congenital Osteopetrosis
Marble Bone	Albers-Schoenberg Disease
Albers-Schonberg Osteopetrosis	Osteosclerosis Fragilis
Ivory Bones

Huntington Disease

Huntington'S Disease	Huntington Chorea
Huntington'S Chorea	HD
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02736	CKB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CKB	VGNC	VGNC:108291
Mus musculus	CKB	MGD	MGI:88407
Bos taurus	CKB	VGNC	VGNC:27384
Rattus norvegicus	CKB	RGD	RGD:2357
Felis catus	CKB	VGNC	VGNC:60913
Macaca fascicularis	CKB	NCBI
Others	CKB	NCBI