CKB - creatine kinase B Gene

Also Known as BCK; B-CK; CKBB; CPK-B; HEL-211; HEL-S-29

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1152

About CKB

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:103,519,667-103,522,830 (from NCBI)

This gene has 18 transcripts (splice variants), 214 orthologues and 4 paralogues. Broad expression in colon (RPKM 268.3), prostate (RPKM 227.9) and 18 other tissues.

Summary

The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in Other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008]

CKB Products (2)

mRNA	Protein	Name
NM_001362531.2	NP_001349460.1	creatine kinase B-type isoform 2
NM_001823.5	NP_001814.2	creatine kinase B-type isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables creatine kinase activity	IDA IDA: Inferred from direct assay	8186255	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	19725078	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in phosphocreatine biosynthetic process	IDA IDA: Inferred from direct assay	8186255	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CKB Protein Structure

ATP-gua_PtransN

ATP-gua_Ptrans

0
100
200
300
381 a.a.

Protein Preferred Names	Protein Names
creatine kinase B-type	brain creatine kinase

CKB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CKB	P12277	CKM	Homo sapiens	P06732	Anti Tag CoIP	35271311
Intra	CKB	P12277	CKM	Homo sapiens	P06732	Anti Tag CoIP	33961781
Intra	CKB	P12277	CKM	Homo sapiens	P06732	Anti Tag CoIP	28514442
Intra	CKB	P12277	ASB9	Homo sapiens	Q96DX5	Y2H Pooling	16189514
Intra	CKB	P12277	ASB9	Homo sapiens	Q96DX5	Validated Y2H	32296183
Intra	CKB	P12277	ASB9	Homo sapiens	Q96DX5	Y2H Prey Pooling	25416956
Intra	CKB	P12277	ASB9	Homo sapiens	Q96DX5	Validated Y2H	25416956
Cross	CKB	P12277	Q03463-PRO_0000278738	Hepatitis C virus	Q03463-PRO_0000278738	Anti Tag CoIP	19264780

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CKB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7897	Creatine kinase B-type/CKB Protein, Human (His)	P12277 (M1-K381)	≥ 90%, as determined by reducing SDS-PAGE.

CKB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80629	Creatine Kinase B type Antibody (YA492)	WB, IHC-P	Human, Mouse, Rat
HY-P80629A	Creatine Kinase B type Antibody (YA492)(PBS only)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Subendocardial Myocardial Infarction
Neonatal Hypoxic And Ischemic Brain Injury	Perinatal Asphyxia Hypoxic-Ischemic Encephalopathy Perinatal Hypoxia Hie Hypoxic And Ischemic Brain Injury In The Newborn Encephalopathy, Hypoxic Ischemic Encephalopathies Hypoxic-Ischemic Hypoxic Ischemic Encephalopathy Hypoxic Ischaemic Brain Injury Brain Hypoxia Cerebral Hypoxia Hypoxic Encephalopathy Hypoxic Brain Damage Hypoxic Brain Injury Brainstem Hypoxia Hypoxic Brainstem Damage
Acute Myocardial Infarction	Cardiac Attack Heart Attack
Cardiac Arrest	Cardiopulmonary Arrest Circulatory Arrest Heart Arrest
Bacterial Meningitis	Meningitis, Bacterial Meningitis Bacterial Bm - [Bacterial Meningitis] Leptomeningitis Bacterial Pachymeningitis Bacterial Arachnoiditis Bacterial
Prostate Rhabdomyosarcoma	Rhabdomyosarcoma Of The Prostate
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Small Cell Cancer Of The Lung	Small Cell Lung Cancer Small Cell Lung Carcinoma Sclc Small-Cell Cancer Of Lung Lung Small Cell Carcinoma Sclc1 Sccl Cancer, Lung, Small Cell Small Cell Carcinoma Of Lung Carcinoma, Small Cell
Mitral Valve Insufficiency	Mitral Regurgitation Congenital Insufficiency Of Mitral Valve Congenital Mitral Insufficiency Congenital Mitral Regurgitation Mitral Valve Incompetence Mitral Valve Regurgitation Mr - [Mitral Regurgitation] Mi - [Mitral Incompetence] Mitral Valve Annular Incompetency Congenital Mitral Valve Incompetence Congenital Mitral Valve Insufficiency Congenital Mitral Valve Regurgitation Congenital Mitral Incompetence
Osteopetrosis	Marble Bone Disease Albers-Schonberg Disease Osteopetroses Marble Bones Osteopetrosis And Related Disorders Congenital Osteopetrosis Marble Bone Albers-Schoenberg Disease Albers-Schonberg Osteopetrosis Osteosclerosis Fragilis Ivory Bones
Huntington Disease	Huntington'S Disease Huntington Chorea Huntington'S Chorea HD Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02634	CHKB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181753	INSP-0154		/	Unkown
HY-RS02736	CKB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17439	Ckb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22118	Chkb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23895	Ckb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CKB	VGNC	VGNC:108291
Mus musculus	CKB	MGD	MGI:88407
Bos taurus	CKB	VGNC	VGNC:27384
Rattus norvegicus	CKB	RGD	RGD:2357
Felis catus	CKB	VGNC	VGNC:60913
Others	CKB	NCBI