HCLS1 - hematopoietic cell-specific Lyn substrate 1 Gene

Homo sapiens

Also known as HS1; p75; CTTNL; lckBP1

Gene ID: 3059 | Gene type: protein coding

About HCLS1

Cytogenetic location: 3q13.33 Genomic coordinates (GRCh38): 3:121,631,399-121,660,903 (from NCBI)

This gene has 12 transcripts (splice variants), 202 orthologues and 4 paralogues. Broad expression in spleen (RPKM 118.5), lymph node (RPKM 107.3) and 16 other tissues.

Summary

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and protein kinase binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of protein phosphorylation; and regulation of transcription, DNA-templated. Located in cytosol; nucleus; and plasma membrane. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022]

HCLS1 Products(2)

mRNA	Protein	Name
NM_001292041.2	NP_001278970.2	hematopoietic lineage cell-specific protein isoform 2
NM_005335.6	NP_005326.3	hematopoietic lineage cell-specific protein isoform 1

HCLS1 Protein Structure

HS1_rep

SH3_1

0
100
200
300
400
486 a.a.

Protein Preferred Names

Protein Names

hematopoietic lineage cell-specific protein

Recombinant HCLS1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70289	HCLS1 Protein, Human (HEK293, His)	P14317 (M1-E486)	≥95%

Related Diseases

Diseases

Alias

Severe Congenital Neutropenia 3

Kostmann Syndrome	Infantile Agranulocytosis
Kostmann Disease	Scn3
Severe Congenital Neutropenia Type 3

Severe Congenital Neutropenia

Congenital Neutropenia	Neutropenia, Severe Congenital
Congenital Agranulocytosis	Infantile Genetic Agranulocytosis
Kostmann Disease	Kostmann'S Agranulocytosis
Kostmann'S Syndrome	Severe Infantile Genetic Neutropenia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06045	HCLS1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HCLS1	VGNC	VGNC:41619
Felis catus	HCLS1	VGNC	VGNC:67543
Bos taurus	HCLS1	VGNC	VGNC:29775
Rattus norvegicus	HCLS1	RGD	RGD:1304754
Mus musculus	HCLS1	MGD	MGI:104568
Macaca mulatta	HCLS1	VGNC	VGNC:73354
Others	HCLS1	NCBI

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