HCLS1 - hematopoietic cell-specific Lyn substrate 1 Gene

Also Known as HS1; p75; CTTNL; lckBP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3059

About HCLS1

Cytogenetic location: 3q13.33 Genomic coordinates (GRCh38): 3:121,631,399-121,660,903 (from NCBI)

This gene has 12 transcripts (splice variants), 202 orthologues and 4 paralogues. Broad expression in spleen (RPKM 118.5), lymph node (RPKM 107.3) and 16 other tissues.

Summary

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and protein kinase binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of protein phosphorylation; and regulation of transcription, DNA-templated. Located in cytosol; nucleus; and plasma membrane. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022]

HCLS1 Products (2)

mRNA	Protein	Name
NM_001292041.2	NP_001278970.2	hematopoietic lineage cell-specific protein isoform 2
NM_005335.6	NP_005326.3	hematopoietic lineage cell-specific protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	23001182	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	23001182	GOA
enables signaling adaptor activity	IMP IMP: Inferred from mutant phenotype	23001182	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actin filament organization	IDA IDA: Inferred from direct assay	23001182	GOA
involved in cellular response to cytokine stimulus	IMP IMP: Inferred from mutant phenotype	23001182	GOA
involved in granulocyte colony-stimulating factor signaling pathway	IMP IMP: Inferred from mutant phenotype	23001182	GOA
involved in negative regulation of leukocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	23001182	GOA
involved in nuclear transport	IMP IMP: Inferred from mutant phenotype	23001182	GOA
involved in positive regulation of granulocyte differentiation	IMP IMP: Inferred from mutant phenotype	23001182	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	23001182	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	23001182	GOA
involved in positive regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	23001182	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23001182	GOA
involved in regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	23001182	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23001182	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23001182	GOA
part of transcription regulator complex	IDA IDA: Inferred from direct assay	23001182	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HCLS1 Protein Structure

HS1_rep

SH3_1

0
100
200
300
400
486 a.a.

Protein Preferred Names	Protein Names
hematopoietic lineage cell-specific protein

HCLS1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HCLS1	P14317	SH3BP2	Homo sapiens	P78314-3	Validated Y2H	32296183
Intra	HCLS1	P14317	SH3BP2	Homo sapiens	P78314-3	Y2H Array	32296183
Intra	HCLS1	P14317	WIPF1	Homo sapiens	O43516	Far-WB	21398607
Intra	HCLS1	P14317	WIPF1	Homo sapiens	O43516	Pull Down	21398607
Intra	HCLS1	P14317	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	HCLS1	P14317	SH2D4A	Homo sapiens	Q9H788	Y2H Prey Pooling	25416956
Intra	HCLS1	P14317	SH2D4A	Homo sapiens	Q9H788	Validated Y2H	25416956
Intra	HCLS1	P14317	SH2D4A	Homo sapiens	Q9H788	Validated Y2H	32296183
Intra	HCLS1	P14317	SH2D4A	Homo sapiens	Q9H788	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HCLS1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70289	HCLS1 Protein, Human (HEK293, His)	AAH16758.1 (M1-E486)	≥ 95%, as determined by reducing SDS-PAGE.

HCLS1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86896	HCLS1 Antibody (YA6589)	WB, IHC-P, ICC/IF, FC, IF-Tissue	Human

Related Diseases

Diseases	Alias
Severe Congenital Neutropenia 3	Kostmann Syndrome Infantile Agranulocytosis Kostmann Disease Scn3 Severe Congenital Neutropenia Type 3
Severe Congenital Neutropenia	Congenital Neutropenia Neutropenia, Severe Congenital Congenital Agranulocytosis Infantile Genetic Agranulocytosis Kostmann Disease Kostmann'S Agranulocytosis Kostmann'S Syndrome Severe Infantile Genetic Neutropenia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06045	HCLS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17702	Hcls1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24166	Hcls1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HCLS1	VGNC	VGNC:41619
Felis catus	HCLS1	VGNC	VGNC:67543
Bos taurus	HCLS1	VGNC	VGNC:29775
Rattus norvegicus	HCLS1	RGD	RGD:1304754
Mus musculus	HCLS1	MGD	MGI:104568
Macaca mulatta	HCLS1	VGNC	VGNC:73354
Others	HCLS1	NCBI