RYK - receptor like tyrosine kinase Gene

Also Known as JTK5; RYK1; JTK5A; D3S3195

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6259

About RYK

Cytogenetic location: 3q22.2 Genomic coordinates (GRCh38): 3:134,157,133-134,250,859 (from NCBI)

This gene has 9 transcripts (splice variants), 211 orthologues and 53 paralogues. Ubiquitous expression in ovary (RPKM 32.1), testis (RPKM 26.7) and 25 other tissues.

Summary

The protein encoded by this gene is an atypical member of the family of growth factor receptor Protein Tyrosine Kinases, differing from Other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]

RYK Products (2)

mRNA	Protein	Name
NM_001005861.3	NP_001005861.1	tyrosine-protein kinase RYK isoform 1 precursor
NM_002958.4	NP_002949.2	tyrosine-protein kinase RYK isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15454084	GOA
NOT enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	10454588	GOA
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	10454588	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	10454588	GOA
NOT involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10454588	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RYK Protein Structure

WIF

Pkinase_Tyr

0
100
200
300
400
500
608 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein kinase RYK	JTK5A protein tyrosine kinase

Recombinant RYK Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73672	RYK Protein, Human (HEK293, Fc)	P34925/NP_002949.2 (P26-R227)	≥ 95%, as determined by reducing SDS-PAGE.

RYK Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82736	RYK Antibody (YA2481)	WB, IHC-F, IHC-P, ICC/IF, IP	Human
HY-P82736A	RYK Antibody (YA2481)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human

Related Diseases

Diseases	Alias
Robinow Syndrome	Acral Dysostosis With Facial And Genital Abnormalities Fetal Face Syndrome Robinow Dwarfism Mesomelic Dwarfism-Small Genitalia Syndrome Robinow-Silverman-Smith Syndrome Costovertebral Segmentation Defect With Mesomelia Covesdem Syndrome Robinow'S Syndrome Robinow-Silverman Syndrome
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate
Norrie Disease	Atrophia Bulborum Hereditaria Episkopi Blindness Pseudoglioma ND Norrie-Warburg Disease Anderson-Warburg Syndrome Fetal Iritis Syndrome Norrie Syndrome Norrie-Warburg Syndrome Ndp Congenital Progressive Oculo-Acoustico-Cerebral Degeneration Norrie'S Disease Oligophrenia Microphthalmus Pseudoglioma Congenita Whitnall-Norman Syndrome
Exudative Vitreoretinopathy	Familial Exudative Vitreoretinopathy Fevr Criswick-Schepens Syndrome Exudative Vitreoretinopathy, Familial Vitreoretinopathy, Exudative ) Exudative Vitreoretinopathy 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12367	RYK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18743	Ryk Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25230	Ryk Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RYK	VGNC	VGNC:84087
Felis catus	RYK	VGNC	VGNC:64836
Mus musculus	RYK	MGD	MGI:101766
Canis familiaris	RYK	VGNC	VGNC:45820
Bos taurus	RYK	VGNC	VGNC:97308
Rattus norvegicus	RYK	RGD	RGD:620549
Others	RYK	NCBI