CELA2A - chymotrypsin like elastase 2A Gene

Also Known as PE-1; AOMS4; ELA2A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 63036

About CELA2A

Cytogenetic location: 1p36.21 Genomic coordinates (GRCh38): 1:15,456,732-15,472,091 (from NCBI)

This gene has 3 transcripts (splice variants), 289 orthologues, 6 paralogues and is associated with 1 phenotype. Restricted expression toward pancreas (RPKM 18580.0).

Summary

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six Elastase genes which encode the structurally similar proteins Elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, Elastase 2A is secreted from the pancreas as a zymogen. In Other species, Elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, May 2009]

CELA2A Products (1)

mRNA Protein Name
NM_033440.3 NP_254275.1 chymotrypsin-like elastase family member 2A preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables endopeptidase activity IDA
IDA: Inferred from direct assay
31358993 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
31358993 GOA
enables serine hydrolase activity IDA
IDA: Inferred from direct assay
20179351 GOA
Biological Process GO Annotation Evidence References Source
involved in insulin catabolic process IDA
IDA: Inferred from direct assay
31358993 GOA
involved in regulation of insulin secretion IDA
IDA: Inferred from direct assay
31358993 GOA
involved in regulation of platelet aggregation IDA
IDA: Inferred from direct assay
31358993 GOA
involved in response to insulin IDA
IDA: Inferred from direct assay
31358993 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
31358993 GOA
located in keratohyalin granule IDA
IDA: Inferred from direct assay
20179351 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CELA2A Protein Structure

Trypsin

Trypsin: Trypsin (29 - 262)

  • 0
  • 100
  • 200
  • 269 a.a.
Protein Preferred Names Protein Names

chymotrypsin-like elastase family member 2A

  • chymotrypsin like elastase family member 2A

Recombinant CELA2A Proteins

Cat. No. Product Name Accession Purity
HY-P72135 CELA2A Protein, Human (His) P08217 (V29-N269) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Abdominal Obesity-Metabolic Syndrome 4

  • AOMS4
Lipoprotein Quantitative Trait Locus

  • Coronary Artery Disease

  • Coronary Artery Anomaly

  • Coronary Artery Disease, Susceptibility To

  • Myocardial Ischemia

  • Congenital Anomaly Of Coronary Artery

  • Coronary Arteriosclerosis

  • Coronary Disease

  • Coronary Heart Disease

  • Coronary Artery Disorder

  • LPAQTL

  • Lpa Deficiency, Congenital

  • Coronary Artery Abnormality

  • Coronary Artery Anomaly, Congenital

  • Chd

  • Coronary Syndrome

  • Congenital Malformations Of Coronary Vessels

  • Malformation Of Coronary Vessels

  • Congenital Coronary Artery Anomaly

  • Congenital Coronary Artery Deformity

  • Congenital Coronary Artery Disorder

  • Abnormal Coronary Artery

  • Congenital Coronary Artery Malposition

  • Congenital Coronary Disease

  • Congenital Anomaly Of Coronary Arteries
Hypertriglyceridemia 1

  • Hypertriglyceridemia

  • Hypertriglyceridemia, Familial

  • Hypertriglyceridemia, Susceptibility To

  • HYTG1

  • FHTR

  • Hypertriglyceridemias Familial
Lipodystrophy, Familial Partial, Type 6

  • FPLD6

  • Lipe-Related Familial Partial Lipodystrophy

  • Familial Partial Lipodystrophy Type 6

  • Lipe-Related Fpld

  • Lipodystrophy, Familial Partial, Associated With Lipe Mutations

  • Familial Partial Lipodystrophy Associated With Lipe Mutations

  • Lipodystrophy, Familial Partial, 6
Diabetes Mellitus

  • Diabetes
Hypertension, Essential

  • Essential Hypertension

  • Hypertension

  • High Blood Pressure

  • Hypertension, Essential, Susceptibility To

  • Hypertensive Disease

  • Primary Hypertension

  • EHT

  • Hypertension, Salt-Sensitive Essential, Susceptibility To

  • Hyperpiesia

  • Idiopathic Hypertension

  • Hypertensive Disorder

  • Hypertension, Essential, Susceptibility To, 3

  • Hypertension, Essential 3

  • Hypertension, Essential, Salt-Sensitive

  • Hypertension, Essential, Susceptibility To, 6

  • Hypertension, Essential 6

  • Hypertension, Salt-Sensitive Essential

  • Hypertension, Susceptibility To

  • Hypertension, Essential, Susceptibility To, 4

  • Hypertension, Essential 4

  • Hypertension, Essential, Susceptibility To, 2

  • Hypertension, Essential 2

  • Hypertension, Essential, Susceptibility To, 1

  • Hypertension, Essential 1

  • Hypertension, Essential, Susceptibility To, 5

  • Hypertension, Essential 5

  • Htn

  • Vascular Hypertensive Disorder

  • Systemic Primary Arterial Hypertension

  • Hbp - [High Blood Pressure]

  • Systemic Arterial Hypertensive Disorder

  • Elevated Blood Pressure

  • Arterial Hypertension Nos

  • Hypertension Nos

  • Benign Hypertension

  • Systemic Arterial Hypertension

  • Systemic Hypertension

  • Artery Htn

  • Benign Htn

  • Vascular Htn

  • Vascular Hypertension

  • Cholesterol Hypertension

  • Cholesterol Htn

  • Idiopathic Htn

  • Malignant Hypertension

  • Malignant Htn

  • Raised Blood Pressure

  • Cardiovascular Hypertension

  • Primary Htn - [Hypertension]

  • High Arterial Tension

  • High Blood Pressure Disorder

  • Ht - [Hypertension]

  • Htn - [Hypertension]

  • Hypertensive Vascular Disease

  • Hypertensive Vascular Degeneration
Type 1 Diabetes Mellitus 10

  • Diabetes Mellitus, Insulin-Dependent, 10

  • IDDM10

  • Insulin-Dependent Diabetes Mellitus 10

  • Diabetes, Mellitus, Insulin-Dependent, Susceptibility To, 10

  • T1D10

  • Diabetes, Mellitus, Insulin-Dependent 10

  • Diabetes Mellitus, Insulin-Dependent, Type 10
Celery Allergy
Type 1 Diabetes Mellitus 11

  • Diabetes Mellitus, Insulin-Dependent, 11

  • Iddm11

  • Insulin-Dependent Diabetes Mellitus 11

  • T1D11

  • Insulin-Dependent Diabetes Mellitus-11
Netherton Syndrome

  • NETH

  • Ns

  • Netherton Disease

  • Comel-Netherton Syndrome

  • Erythroderma, Ichthyosiform, With Hypotrichosis And Hyper-Ige

  • Bamboo Hair Syndrome

  • Ichthyosis Linearis Circumflexa

  • Ichthyosiform Erythroderma With Hypotrichosis And Hyper-Ige

  • Ilc

  • Nts

  • N Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02456 CELA2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18699 Cela2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25186 Cela2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CELA2A MGD MGI:95316
Rattus norvegicus CELA2A RGD RGD:2548
Others CELA2A NCBI