BRCC3 - BRCA1/BRCA2-containing complex subunit 3 Gene

Also Known as C6.1A; BRCC36; CXorf53

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79184

About BRCC3

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:155,071,508-155,123,077 (from NCBI)

This gene has 7 transcripts (splice variants), 208 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in colon (RPKM 4.9), esophagus (RPKM 3.5) and 25 other tissues.

Summary

This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin Ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]

BRCC3 Products (3)

mRNA	Protein	Name
NM_001018055.3	NP_001018065.1	lys-63-specific deubiquitinase BRCC36 isoform 2
NM_001242640.2	NP_001229569.1	lys-63-specific deubiquitinase BRCC36 isoform 3
NM_024332.4	NP_077308.1	lys-63-specific deubiquitinase BRCC36 isoform 1

BRCC3 Protein Structure

JAB

0
100
200
300
316 a.a.

Protein Preferred Names	Protein Names
lys-63-specific deubiquitinase BRCC36	BRCA1-A complex subunit BRCC36

BRCC3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BRCC3	P46736	ABRAXAS2	Homo sapiens	Q15018	Lumier	37398436
Intra	BRCC3	P46736	ABRAXAS2	Homo sapiens	Q15018	Anti Tag CoIP	19615732
Intra	BRCC3	P46736	ABRAXAS2	Homo sapiens	Q15018	BRET	37398436
Intra	BRCC3	P46736	ABRAXAS1	Homo sapiens	Q6UWZ7	Anti Tag CoIP	19615732
Intra	BRCC3	P46736	ANKRD11	Homo sapiens	X5D778	Validated Y2H	32296183
Intra	BRCC3	P46736	SHMT2	Homo sapiens	P34897	Anti Tag CoIP	19615732
Intra	BRCC3	P46736	UIMC1	Homo sapiens	Q96RL1-1	Anti Bait CoIP	18077395
Intra	BRCC3	P46736	UIMC1	Homo sapiens	Q96RL1-1	Anti Tag CoIP	19202061

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BRCC3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72107	BRCC36 Protein, Human (His-SUMO)	P46736 (A2-E316)	≥ 90%, as determined by reducing SDS-PAGE.

BRCC3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82553	BRCC36 Antibody (YA2298)	WB, FC	Human, Mouse, Rat
HY-P82553A	BRCC36 Antibody (YA2298)(PBS only)	WB, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Moyamoya Disease 4 With Short Stature, Hypergonadotropic Hypogonadism, And Facial Dysmorphism	Moyamoya Angiopathy-Short Stature-Facial Dysmorphism-Hypergonadotropic Hypogonadism Syndrome MYMY4 Chromosome Xq28 Deletion Syndrome, 3.4-Kb Syndromic Moyamoya Disease Moyamoya Disease 4 Moyamoya Disease-Short Stature-Facial Dysmorphism-Hypergonadotropic Hypogonadism
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01595	BRCC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03694	DEPDC1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17602	Brcc3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24062	Brcc3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BRCC3	VGNC	VGNC:26555
Rattus norvegicus	BRCC3	RGD	RGD:1588543
Mus musculus	BRCC3	MGD	MGI:2389572
Macaca mulatta	BRCC3	VGNC	VGNC:103793
Felis catus	BRCC3	VGNC	VGNC:97368
Others	BRCC3	NCBI