ABRAXAS2 - abraxas 2, BRISC complex subunit Gene

Also Known as ABRO1; FAM175B; KIAA0157

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23172

Summary

Enables microtubule binding activity and polyubiquitin modification-dependent protein binding activity. Involved in nuclear chromosome segregation; protein K63-linked deubiquitination; and response to ischemia. Located in cytosol; microtubule cytoskeleton; and midbody. Part of BRISC complex. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in thyroid (RPKM 8.5), lymph node (RPKM 6.8) and 25 other tissues.

ABRAXAS2 Products (1)

mRNA Protein Name
NM_032182.4 NP_115558.3 BRISC complex subunit Abraxas 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables microtubule binding IDA
IDA: Inferred from direct assay
26195665 GOA
enables polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
19261749 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19615732 GOA
Biological Process GO Annotation Evidence References Source
involved in attachment of spindle microtubules to kinetochore IMP
IMP: Inferred from mutant phenotype
26195665 GOA
involved in chromosome segregation IMP
IMP: Inferred from mutant phenotype
26195665 GOA
involved in mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
26195665 GOA
involved in mitotic spindle assembly IMP
IMP: Inferred from mutant phenotype
26195665 GOA
involved in protein K63-linked deubiquitination IMP
IMP: Inferred from mutant phenotype
24075985 GOA
involved in response to ischemia IMP
IMP: Inferred from mutant phenotype
21195082 GOA
Cellular Component GO Annotation Evidence References Source
part of BRISC complex IDA
IDA: Inferred from direct assay
19214193 GOA
colocalizes with centrosome IDA
IDA: Inferred from direct assay
26195665 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
21195082 GOA
colocalizes with microtubule minus-end IDA
IDA: Inferred from direct assay
26195665 GOA
colocalizes with midbody IDA
IDA: Inferred from direct assay
26195665 GOA
colocalizes with spindle pole centrosome IDA
IDA: Inferred from direct assay
26195665 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABRAXAS2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ABRAXAS2 Q15018 DCUN1D1 Homo sapiens Q96GG9
Validated Y2H
32296183
Intra
ABRAXAS2 Q15018 BRCC3 Homo sapiens P46736
Lumier
37398436
Intra
ABRAXAS2 Q15018 BRCC3 Homo sapiens P46736
BRET
37398436
Intra
ABRAXAS2 Q15018 BRCC3 Homo sapiens P46736
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction