KREMEN1 - kringle containing transmembrane protein 1 Gene

Also Known as KRM1; ECTD13; KREMEN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 83999

About KREMEN1

Cytogenetic location: 22q12.1 Genomic coordinates (GRCh38): 22:29,073,035-29,168,333 (from NCBI)

This gene has 6 transcripts (splice variants), 195 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in skin (RPKM 9.8), esophagus (RPKM 9.6) and 23 other tissues.

Summary

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (Wnt)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical Wnt signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Mutations in this gene result in ectodermal dysplasia. This protein has also been found to be a functional receptor for Coxsackievirus A10 and may be an alternative entry receptor for SARS-CoV-2. [provided by RefSeq, Nov 2021]

KREMEN1 Products (2)

mRNA	Protein	Name
NM_001039570.3	NP_001034659.2	kremen protein 1 isoform 3 precursor
NM_032045.5	NP_114434.3	kremen protein 1 isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17804805	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KREMEN1 Protein Structure

Kringle

WSC

CUB

0
100
200
300
400
473 a.a.

Protein Preferred Names	Protein Names
kremen protein 1	dickkopf receptor

KREMEN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KREMEN1	Q96MU8	DKK1	Homo sapiens	O94907	SPR	27524201
Intra	KREMEN1	Q96MU8	DKK1	Homo sapiens	O94907	Anti Tag CoIP	17804805

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KREMEN1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76471	KREMEN1 Protein, Human (HEK293, His)	Q96MU8-2/NP_114434.3 (A20-T394)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Ectodermal Dysplasia 13, Hair/Tooth Type	ECTD13 Ectodermal Dysplasia 13
Hand, Foot And Mouth Disease	Vesicular Stomatitis And Exanthem
Ectodermal Dysplasia	Congenital Ectodermal Defect Congenital Ectodermal Dysplasia Ectodermal Dysplasia Syndrome Dysplasia, Ectodermal
Osteoporosis-Pseudoglioma Syndrome	OPPG Ops Osteoporosis With Pseudoglioma Osteogenesis Imperfecta, Ocular Form Ocular Form Of Osteogenesis Imperfecta Osteogenesis Imperfecta Ocular Form Osteoporosis Pseudoglioma Syndrome Pseudoglioma With Bone Fragility
Hyperostosis	Hypertrophy Of Bone Bone Hypertrophy Bone Thickening Periosteum Thickening
Mouth Disease	Mouth Diseases Mouth Disorders
Schopf-Schulz-Passarge Syndrome	SSPS Eccrine Tumors With Ectodermal Dysplasia Eccrine Tumors-Ectodermal Dysplasia Keratosis Palmoplantaris-Cystic Eyelids-Hypodontia-Hypotrichosis Syndrome Palmoplantar Hyperkeratosis-Cystic Eyelids-Hypodontia-Hypotrichosis Syndrome Palmoplantar Keratoderma-Cystic Eyelids-Hypodontia-Hypotrichosis Syndrome Keratosis Palmoplantaris With Cystic Eyelids, Hypodontia, And Hypotrichosis Keratosis Palmoplantaris With Cystic Eyelids, Hypodontia And Hypotrichosis
Sclerosteosis 2	SOST2 Sclerosteosis, Type 2
Gapo Syndrome	GAPOS Growth Retardation, Alopecia, Pseudoanodontia, And Optic Atrophy Growth Delay-Alopecia-Pseudoanodontia-Optic Atrophy Syndrome Growth Retardation, Alopecia, Pseudoanodontia And Optic Atrophy
Van Buchem Disease	Hyperostosis Corticalis Generalisata Hyperphosphatasemia Tarda VBCH Sost-Related Sclerosing Bone Dysplasia Endosteal Hyperostosis Autosomal Recessive Sclerosteosis Endosteal Hyperostosis, Autosomal Recessive Hyperotosis Corticalis Generalisata Familiaris Sost Sclerosing Bone Dysplasia Smith-Lemli-Opitz Syndrome
Sclerosteosis	Cortical Hyperostosis With Syndactyly Sost Cortical Hyperostosis-Syndactyly Syndrome
Tooth Agenesis	Oligodontia Hypodontia Selective Tooth Agenesis Tooth Agenesis, Selective Familial Tooth Agenesis Anodontia Congenital Absence Of One Tooth

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07428	KREMEN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20635	Kremen1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27144	Kremen1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KREMEN1	VGNC	VGNC:74066
Mus musculus	KREMEN1	MGD	MGI:1933988
Bos taurus	KREMEN1	VGNC	VGNC:53911
Felis catus	KREMEN1	VGNC	VGNC:63167
Rattus norvegicus	KREMEN1	RGD	RGD:620789
Canis familiaris	KREMEN1	VGNC	VGNC:42511
Others	KREMEN1	NCBI