KREMEN1 - kringle containing transmembrane protein 1 Gene

Homo sapiens

Also known as KRM1; ECTD13; KREMEN

Gene ID: 83999 | Gene type: protein coding

About KREMEN1

Cytogenetic location: 22q12.1 Genomic coordinates (GRCh38): 22:29,073,035-29,168,333 (from NCBI)

This gene has 6 transcripts (splice variants), 195 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in skin (RPKM 9.8), esophagus (RPKM 9.6) and 23 other tissues.

Summary

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (Wnt)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical Wnt signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Mutations in this gene result in ectodermal dysplasia. This protein has also been found to be a functional receptor for Coxsackievirus A10 and may be an alternative entry receptor for SARS-CoV-2. [provided by RefSeq, Nov 2021]

KREMEN1 Products(2)

mRNA	Protein	Name
NM_001039570.3	NP_001034659.2	kremen protein 1 isoform 3 precursor
NM_032045.5	NP_114434.3	kremen protein 1 isoform 2 precursor

KREMEN1 Protein Structure

Kringle

WSC

CUB

0
100
200
300
400
473 a.a.

Protein Preferred Names

Protein Names

kremen protein 1

dickkopf receptor

Recombinant KREMEN1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76471	KREMEN1 Protein, Human (HEK293, His)	Q96MU83-3/NP_114434.3 (A20-T394)	≥95%

Related Diseases

Diseases

Alias

Ectodermal Dysplasia 13, Hair/Tooth Type

ECTD13

Ectodermal Dysplasia 13

Hand, Foot And Mouth Disease

Vesicular Stomatitis And Exanthem

Ectodermal Dysplasia

Congenital Ectodermal Defect	Congenital Ectodermal Dysplasia
Ectodermal Dysplasia Syndrome	Dysplasia, Ectodermal

Osteoporosis-Pseudoglioma Syndrome

OPPG	Ops
Osteoporosis With Pseudoglioma	Osteogenesis Imperfecta, Ocular Form
Ocular Form Of Osteogenesis Imperfecta	Osteogenesis Imperfecta Ocular Form
Osteoporosis Pseudoglioma Syndrome	Pseudoglioma With Bone Fragility

Hyperostosis

Hypertrophy Of Bone	Bone Hypertrophy
Bone Thickening	Periosteum Thickening

Mouth Disease

Mouth Diseases

Mouth Disorders

Schopf-Schulz-Passarge Syndrome

SSPS	Eccrine Tumors With Ectodermal Dysplasia
Eccrine Tumors-Ectodermal Dysplasia	Keratosis Palmoplantaris-Cystic Eyelids-Hypodontia-Hypotrichosis Syndrome
Palmoplantar Hyperkeratosis-Cystic Eyelids-Hypodontia-Hypotrichosis Syndrome	Palmoplantar Keratoderma-Cystic Eyelids-Hypodontia-Hypotrichosis Syndrome
Keratosis Palmoplantaris With Cystic Eyelids, Hypodontia, And Hypotrichosis	Keratosis Palmoplantaris With Cystic Eyelids, Hypodontia And Hypotrichosis

Sclerosteosis 2

SOST2

Sclerosteosis, Type 2

Gapo Syndrome

GAPOS	Growth Retardation, Alopecia, Pseudoanodontia, And Optic Atrophy
Growth Delay-Alopecia-Pseudoanodontia-Optic Atrophy Syndrome	Growth Retardation, Alopecia, Pseudoanodontia And Optic Atrophy

Van Buchem Disease

Hyperostosis Corticalis Generalisata	Hyperphosphatasemia Tarda
VBCH	Sost-Related Sclerosing Bone Dysplasia
Endosteal Hyperostosis Autosomal Recessive	Sclerosteosis
Endosteal Hyperostosis, Autosomal Recessive	Hyperotosis Corticalis Generalisata Familiaris
Sost Sclerosing Bone Dysplasia	Smith-Lemli-Opitz Syndrome

Sclerosteosis

Cortical Hyperostosis With Syndactyly	Sost
Cortical Hyperostosis-Syndactyly Syndrome

Tooth Agenesis

Oligodontia	Hypodontia
Selective Tooth Agenesis	Tooth Agenesis, Selective
Familial Tooth Agenesis	Anodontia
Congenital Absence Of One Tooth

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07428	KREMEN1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KREMEN1	VGNC	VGNC:74066
Mus musculus	KREMEN1	MGD	MGI:1933988
Bos taurus	KREMEN1	VGNC	VGNC:53911
Felis catus	KREMEN1	VGNC	VGNC:63167
Rattus norvegicus	KREMEN1	RGD	RGD:620789
Canis familiaris	KREMEN1	VGNC	VGNC:42511
Others	KREMEN1	NCBI

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