CD34 - CD34 molecule Gene
Species: Homo sapiens
About CD34
This gene has 4 transcripts (splice variants) and 255 orthologues. Broad expression in placenta (RPKM 110.3), fat (RPKM 76.9) and 19 other tissues.
Summary
The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
CD34 Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001025109.2 | NP_001020280.1 | hematopoietic progenitor cell antigen CD34 isoform a precursor |
| NM_001773.3 | NP_001764.1 | hematopoietic progenitor cell antigen CD34 isoform b precursor |
| NM_001025109.2 | NP_001020280.1 | hematopoietic progenitor cell antigen CD34 isoform a precursor |
| NM_001773.3 | NP_001764.1 | hematopoietic progenitor cell antigen CD34 isoform b precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables RNA polymerase II-specific DNA-binding transcription factor binding |
IPI
IPI: Inferred from physical interaction
|
21873977 | GOA |
| enables carbohydrate binding |
IDA
IDA: Inferred from direct assay
|
15249540 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
7525669 | GOA |
| located in external side of plasma membrane |
IDA
IDA: Inferred from direct assay
|
10337918 | GOA |
| located in intercellular bridge |
IDA
IDA: Inferred from direct assay
|
7525669 | GOA |
| located in perinuclear region of cytoplasm |
IDA
IDA: Inferred from direct assay
|
7525669 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
1868864 | GOA |
CD34 Protein Structure
CD34_antigen: CD34/Podocalyxin family (190 - 385)
- 0
- 100
- 200
- 300
- 385 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
hematopoietic progenitor cell antigen CD34 |
|
CD34 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CD34 | P28906 | AGR2 | Homo sapiens | O95994 | 32296183 | |
|
Intra
|
CD34 | P28906 | AGR2 | Homo sapiens | O95994 | 32296183 |
Recombinant CD34 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P72734 | CD34 Protein, Human (HEK293, His) | P28906 (S32-T290) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P74306 | CD34 Protein, Human (HEK293, Fc) | P28906 (S32-T290) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P77524 | CD34 Protein, Human (Biotinylated, HEK293, His) | P28906 (S32-T290) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P77525 | CD34 Protein, Human (Biotinylated, HEK293, Fc) | P28906 (S32-T290) | ≥ 90%, as determined by reducing SDS-PAGE. |
CD34 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81098 | CD34 Antibody | WB, IHC-P, IHC-F, ICC/IF | Human, Mouse |
| HY-P84238 | CD34 Antibody (YA3935) | WB, FC, ELISA | Human, Mouse, Rat |
| HY-P84238A | CD34 Antibody (YA3935)(PBS only) | WB, FC, ELISA | Human, Mouse, Rat |
| HY-P86128 | CD34 Antibody (YA5820) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
| HY-P86668 | CD34 Antibody (YA6360) | WB, IHC-P, IHC-F, IF-Tissue, IP | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Hemangiopericytoma, Malignant |
|
|
| Dermatofibrosarcoma Protuberans |
|
|
| Neurofibroma |
|
|
| Cutaneous Fibrous Histiocytoma |
|
|
| Angiosarcoma |
|
|
| Perivascular Tumor |
|
|
| Fasciitis |
|
|
| Spindle Cell Lipoma |
|
|
| Hemangioendothelioma |
|
|
| Fibroma |
|
|
| Gastrointestinal Stromal Tumor |
|
|
| Breast Sarcoma |
|
|
| Orbital Cancer |
|
|
| Mesenchymal Cell Neoplasm |
|
|
| Skin Sarcoma |
|
|
| Breast Myofibroblastoma |
|
|
| Vascular Cancer |
|
|
| Lung Meningioma |
|
|
| Dedifferentiated Liposarcoma |
|
|
| Kidney Hemangiopericytoma |
|
|
| Breast Hemangioma |
|
|
| B-Lymphoblastic Leukemia/Lymphoma |
|
|
| Leiomyoma |
|
|
| Benign Fibrous Mesothelioma |
|
|
| Epithelioid Sarcoma |
|
|
| Pleomorphic Lipoma |
|
|
| Conventional Fibrosarcoma |
|
|
| Sialadenitis |
|
|
| Acute Leukemia |
|
|
| Breast Capillary Hemangioma |
|
|
| Liposarcoma |
|
|
| Angiomyoma |
|
|
| Malignant Peripheral Nerve Sheath Tumor |
|
|
| Pineal Region Choriocarcinoma |
|
|
| Neurilemmoma |
|
|
| Hobnail Hemangioma |
|
|
| Breast Angiosarcoma |
|
|
| Nasal Cavity Benign Neoplasm |
|
|
| Hemangioma |
|
|
| Bacillary Angiomatosis |
|
|
| Fibrous Histiocytoma |
|
|
| Cutaneous Leiomyosarcoma |
|
|
| Hemangioma Of Spleen |
|
|
| Mastocytosis, Cutaneous |
|
|
| Subungual Glomus Tumor |
|
|
| Benign Perivascular Tumor |
|
|
| Connective Tissue Benign Neoplasm |
|
|
| Prostate Stromal Sarcoma |
|
|
| Hemorrhagic Cystitis |
|
|
| Glomangioma |
|
|
| Meninges Hemangiopericytoma |
|
|
| Mixed Liposarcoma |
|
|
| Small Intestine Leiomyosarcoma |
|
|
| Glomangiomyoma |
|
|
| Sclerosing Liposarcoma |
|
|
| Pacinian Tumor |
|
|
| Hemangioblastoma |
|
|
| Solitary Fibrous Tumor/Hemangiopericytoma |
|
|
| Buerger Disease |
|
|
| Riedel'S Fibrosing Thyroiditis |
|
|
| Bartholin'S Duct Cyst |
|
|
| Spindle Cell Liposarcoma |
|
|
| Gallbladder Leiomyosarcoma |
|
|
| Heart Sarcoma |
|
|
| Chordoid Glioma |
|
|
| Intravascular Fasciitis |
|
|
| Lipomatosis, Multiple |
|
|
| Extraosseous Osteosarcoma |
|
|
| Cardiovascular Organ Benign Neoplasm |
|
|
| Follicular Dendritic Cell Sarcoma |
|
|
| Fibrous Meningioma |
|
|
| Infiltrating Angiolipoma |
|
|
| Myoma |
|
|
| Skin Epithelioid Hemangioma |
|
|
| Lung Sarcoma |
|
|
| Colonic Lymphangioma |
|
|
| Prostate Angiosarcoma |
|
|
| Intravascular Angioleiomyoma |
|
|
| Cellular Schwannoma |
|
|
| Myelodysplastic Syndrome |
|
|
| Breast Malignant Phyllodes Tumor |
|
|
| Ischemic Fasciitis |
|
|
| Vulvar Proximal-Type Epithelioid Sarcoma |
|
|
| Central Epithelioid Sarcoma |
|
|
| Glomangiomatosis |
|
|
| Gallbladder Leiomyoma |
|
|
| Limb Ischemia |
|
|
| Leukemia, Chronic Myeloid |
|
|
| Spindle Cell Thymoma |
|
|
| Prostate Leiomyoma |
|
|
| Kaposi Sarcoma |
|
|
| Heart Cancer |
|
|
| Myxofibrosarcoma |
|
|
| Central Nervous System Fibrosarcoma |
|
|
| Glomeruloid Hemangioma |
|
|
| Lymphangiosarcoma |
|
|
| Plexiform Schwannoma |
|
|
| Cavernous Hemangioma |
|
|
| Intramuscular Hemangioma |
|
|
| Ovarian Angiosarcoma |
|
|
| Nephrogenic Adenofibroma |
|
|
| Glomangiosarcoma |
|
|
| Retroperitoneal Hemangiopericytoma |
|
|
| Myofibroma |
|
|
| Capillary Hemangioma |
|
|
| Liver Leiomyoma |
|
|
| Angiolipoma |
|
|
| Basal Cell Carcinoma |
|
|
| Acquired Immunodeficiency Syndrome |
|
|
| Orbital Disease |
|
|
| Granulomatosis With Polyangiitis |
|
|
| Pseudosarcomatous Fibromatosis |
|
|
| Capillary Disease |
|
|
| Malignant Mesenchymoma |
|
|
| Thyroid Angiosarcoma |
|
|
| Jejunal Neoplasm |
|
|
| Myelofibrosis |
|
|
| Colon Leiomyosarcoma |
|
|
| Chronic Lacrimal Gland Enlargement |
|
|
| Well-Differentiated Liposarcoma |
|
|
| Proliferative Fasciitis |
|
|
| Sarcomatoid Squamous Cell Skin Carcinoma |
|
|
| Monophasic Synovial Sarcoma |
|
|
| Infiltrating Lipoma |
|
|
| Benign Teratoma |
|
|
| Conventional Angiosarcoma |
|
|
| Histiocytoid Hemangioma |
|
|
| Mechanical Ectropion |
|
|
| Prostate Sarcoma |
|
|
| Infantile Myofibromatosis |
|
|
| Aorta Angiosarcoma |
|
|
| Pulmonary Artery Leiomyosarcoma |
|
|
| Lymphangioma |
|
|
| Ovarian Solid Teratoma |
|
|
| Inflammatory Myofibroblastic Tumor |
|
|
| Thyroid Sarcoma |
|
|
| Morpheaform Basal Cell Carcinoma |
|
|
| Cystic Lymphangioma |
|
|
| Dartoic Leiomyoma |
|
|
| Colon Kaposi Sarcoma |
|
|
| Epidural Spinal Canal Neoplasm |
|
|
| Secondary Hypertrophic Osteoarthropathy |
|
|
| Myeloid Sarcoma |
|
|
| Chorioangioma |
|
|
| Mediastinal Cancer |
|
|
| Angiomatous Meningioma |
|
|
| Epithelioid Hemangioendothelioma |
|
|
| Cervical Polyp |
|
|
| Perineurioma |
|
|
| Spindle Cell Synovial Sarcoma |
|
|
| Testicular Fibroma |
|
|
| Liver Sarcoma |
|
|
| Spindle Cell Hemangioma |
|
|
| Childhood Angiosarcoma |
|
|
| Gastric Leiomyoma |
|
|
| Intussusception |
|
|
| Gastric Liposarcoma |
|
|
| Epulis |
|
|
| Venous Hemangioma |
|
|
| Retroperitoneal Leiomyosarcoma |
|
|
| Chordoid Meningioma |
|
|
| Retroperitoneal Sarcoma |
|
|
| Potter'S Syndrome |
|
|
| Congenital Granular Cell Tumor |
|
|
| Leukemia, Acute Lymphoblastic |
|
|
| Hepatic Angiomyolipoma |
|
|
| Vulvar Sarcoma |
|
|
| Third Ventricle Chordoid Glioma |
|
|
| Capillary Lymphangioma |
|
|
| Epithelioid Leiomyosarcoma |
|
|
| Liver Leiomyosarcoma |
|
|
| Liposarcoma Of Bone |
|
|
| Skin Tag |
|
|
| Epiglottis Cancer |
|
|
| Thoracic Benign Neoplasm |
|
|
| Lung Leiomyosarcoma |
|
|
| Vulvar Granular Cell Tumor |
|
|
| Neurofibroma Of The Heart |
|
|
| Penis Sarcoma |
|
|
| Lipofibromatosis-Like Neural Tumor |
|
|
| Glomus Tumor |
|
|
| Epithelioid Malignant Peripheral Nerve Sheath Tumor |
|
|
| Adenoid Squamous Cell Carcinoma |
|
|
| Pulmonary Vein Leiomyosarcoma |
|
|
| Intravenous Leiomyomatosis |
|
|
| Muscle Cancer |
|
|
| Peliosis Hepatis |
|
|
| Synovium Cancer |
|
|
| Central Nervous System Angiosarcoma |
|
|
| Spindle Cell Sarcoma |
|
|
| Bartonellosis |
|
|
| Epithelioid Neurofibroma |
|
|
| Bone Marrow Cancer |
|
|
| Breast Benign Neoplasm |
|
|
| Diffuse Peritoneal Leiomyomatosis |
|
|
| Spinal Cord Sarcoma |
|
|
| Neurofibroma Of The Esophagus |
|
|
| Localized Scleroderma |
|
|
| Biphasic Synovial Sarcoma |
|
|
| Malignant Spindle Cell Melanoma |
|
|
| Adenosine Deaminase Deficiency |
|
|
| Myelophthisic Anemia |
|
|
| Systemic Scleroderma |
|
|
| Granulomatous Disease, Chronic, X-Linked |
|
|
| Leukemia, Acute Myeloid |
|
|
| Malignant Inflammatory Fibrous Histiocytoma |
|
|
| Sarcomatoid Renal Cell Carcinoma |
|
|
| Adult Fibrosarcoma |
|
|
| Neuronal Intestinal Dysplasia, Type B |
|
|
| Acute Erythroid Leukemia |
|
|
| Thrombocytopenia |
|
|
| Neurofibrosarcoma |
|
|
| Perivascular Epithelioid Cell Tumor |
|
|
| Breast Leiomyosarcoma |
|
|
| Aleukemic Leukemia Cutis |
|
|
| Heart Fibrosarcoma |
|
|
| Central Nervous System Leukemia |
|
|
| Desmoid Tumor |
|
|
| Sweat Gland Benign Neoplasm |
|
|
| Deep Leiomyoma |
|
|
| Acute Biphenotypic Leukemia |
|
|
| Spermatic Cord Cancer |
|
|
| Colon Leiomyoma |
|
|
| Liver Angiosarcoma |
|
|
| Metatypical Basal Cell Carcinoma |
|
|
| Psammomatous Meningioma |
|
|
| Pleomorphic Liposarcoma |
|
|
| Skin Benign Neoplasm |
|
|
| Histiocytic And Dendritic Cell Cancer |
|
|
| Smooth Muscle Tumor |
|
|
| Chondroid Lipoma |
|
|
| Severe Combined Immunodeficiency, X-Linked |
|
|
| Erythema Elevatum Diutinum |
|
|
| Phagocyte Bactericidal Dysfunction |
|
|
| Malignant Triton Tumor |
|
|
| Scrotum Neoplasm |
|
|
| Meckel Diverticulum |
|
|
| Deficiency Anemia |
|
|
| Small Intestine Benign Neoplasm |
|
|
| Leukocyte Disease |
|
|
| Neurilemmoma Of The Fifth Cranial Nerve |
|
|
| Trigeminal Nerve Neoplasm |
|
|
| Lymphoma, Non-Hodgkin, Familial |
|
|
| Exophthalmos |
|
|
| Blood Coagulation Disease |
|
|
| Hepatic Veno-Occlusive Disease |
|
|
| Angiokeratoma Circumscriptum |
|
|
| Neuroma |
|
|
| Malignant Syringoma |
|
|
| Sclerosing Hepatic Carcinoma |
|
|
| Hemoglobinopathy |
|
|
| Liver Inflammatory Pseudotumor |
|
|
| Chronic Leukemia |
|
|
| Myeloproliferative Syndrome, Transient |
|
|
| Breast Hemangiopericytoma |
|
|
| Vagina Leiomyoma |
|
|
| Liver Lipoma |
|
|
| Small Intestine Leiomyoma |
|
|
| Ossifying Fibroma |
|
|
| Meninges Sarcoma |
|
|
| Childhood Fibrosarcoma |
|
|
| Acute Serous Otitis Media |
|
|
| Congenital Fibrosarcoma |
|
|
| Inflammatory Liposarcoma |
|
|
| Cystic Teratoma |
|
|
| Multifocal Osteogenic Sarcoma |
|
|
| Aplastic Anemia |
|
|
| Amegakaryocytic Thrombocytopenia, Congenital |
|
|
| Colorectal Cancer |
|
|
| Jugular Foramen Meningioma |
|
|
| Germ Cell And Embryonal Cancer |
|
|
| Blood Platelet Disease |
|
|
| Paraganglioma And Gastric Stromal Sarcoma |
|
|
| Middle Ear Cholesterol Granuloma |
|
|
| Meningioma, Familial |
|
|
| Clear Cell Meningioma |
|
|
| Bone Benign Neoplasm |
|
|
| Myxoid Liposarcoma Of The Ovary |
|
|
| Liposarcoma Of The Ovary |
|
|
| Myelodysplastic/Myeloproliferative Neoplasm |
|
|
| Hepatic Vascular Disease |
|
|
| Dysembryoplastic Neuroepithelial Tumor |
|
|
| Gastric Cancer |
|
|
| Liver Benign Neoplasm |
|
|
| Breast Fibroadenoma |
|
|
| Sickle Cell Anemia |
|
|
| Combined Immunodeficiency |
|
|
| Myxoid Liposarcoma |
|
|
| Gastric Hemangioma |
|
|
| Acute Basophilic Leukemia |
|
|
| Skeletal Muscle Cancer |
|
|
| Childhood Leukemia |
|
|
| Vaginal Endometrial Stromal Sarcoma |
|
|
| Pericardial Effusion |
|
|
| Pyogenic Granuloma |
|
|
| Chondrosarcoma, Extraskeletal Myxoid |
|
|
| Congenital Hemolytic Anemia |
|
|
| Blood Protein Disease |
|
|
| Uterine Benign Neoplasm |
|
|
| Acquired Hemangioma |
|
|
| Beta-Thalassemia Major |
|
|
| Mucocele Of Appendix |
|
|
| Reproductive Organ Benign Neoplasm |
|
|
| Vagina Sarcoma |
|
|
| Sarcoma, Synovial |
|
|
| Peripheral Nervous System Benign Neoplasm |
|
|
| Autonomic Nervous System Benign Neoplasm |
|
|
| Germ Cell Cancer |
|
|
| Intestinal Obstruction |
|
|
| Bile Duct Cystadenoma |
|
|
| Myocardial Infarction |
|
|
| Parietal Lobe Neoplasm |
|
|
| Cell Type Benign Neoplasm |
|
|
| Sweat Gland Disease |
|
|
| Adult Acute Lymphocytic Leukemia |
|
|
| Cecal Disease |
|
|
| Central Nervous System Hemangioma |
|
|
| Peripheral Nervous System Neoplasm |
|
|
| Metachromatic Leukodystrophy |
|
|
| Hepatocellular Carcinoma |
|
|
| Respiratory System Benign Neoplasm |
|
|
| Pancytopenia |
|
|
| Chronic Granulomatous Disease |
|
|
| Chronic Myelomonocytic Leukemia |
|
|
| Essential Thrombocythemia |
|
|
| Vulvar Leiomyoma |
|
|
| Langerhans Cell Histiocytosis |
|
|
| Mucinous Tubular And Spindle Renal Cell Carcinoma |
|
|
| Endobronchial Leiomyoma |
|
|
| Ovarian Cancer |
|
|
| Vein Disease |
|
|
| Thymus Sarcomatoid Carcinoma |
|
|
| Precursor T-Cell Acute Lymphoblastic Leukemia |
|
|
| Myeloproliferative Neoplasm |
|
|
| Myeloid And Lymphoid Neoplasms Associated With Fgfr1 Abnormalities |
|
|
| Neurofibromatosis, Type I |
|
|
| Acute Megakaryocytic Leukemia |
|
|
| Invasive Malignant Thymoma |
|
|
| Juvenile Myelomonocytic Leukemia |
|
|
| Cutaneous Ganglioneuroma |
|
|
| Aggressive Systemic Mastocytosis |
|
|
| Neuroblastoma |
|
|
| Benign Peritoneal Mesothelioma |
|
|
| Arteriovenous Malformation |
|
|
| Tibial Adamantinoma |
|
|
| Epithelioid Cell Synovial Sarcoma |
|
|
| Endometrial Stromal Sarcoma |
|
|
| Muscular Disease |
|
|
| Adult Malignant Schwannoma |
|
|
| Chronic Congestive Splenomegaly |
|
|
| Inguinal Hernia |
|
|
| Embryonal Rhabdomyosarcoma |
|
|
| Severe Congenital Neutropenia |
|
|
| Shwachman-Diamond Syndrome 1 |
|
|
| Severe Combined Immunodeficiency |
|
|
| Immune Deficiency Disease |
|
|
| Cervical Adenosarcoma |
|
|
| Mantle Cell Lymphoma |
|
|
| Hemolytic Anemia |
|
|
| Wilms Tumor 1 |
|
|
| Diamond-Blackfan Anemia |
|
|
| Peripheral Nervous System Disease |
|
|
| Diabetes Mellitus |
|
|
| Moyamoya Disease 1 |
|
|
| Hypertension, Essential |
|
|
| Breast Cancer |
|
|
| Brittle Bone Disorder |
|
|
| Acute Promyelocytic Leukemia |
|
|
| Dyskeratosis Congenita |
|
|
| Connective Tissue Disease |
|
|
| Skin Disease |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
| Nervous System Disease |
|
|
| Fanconi Anemia, Complementation Group A |
|
|
| Eye Disease |
|
|
| Interstitial Lung Disease 2 |
|
|
| Dilated Cardiomyopathy |
|
|
| Retinitis Pigmentosa |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | CD34 | VGNC | VGNC:27025 |
| Rattus norvegicus | CD34 | RGD | RGD:1306863 |
| Macaca mulatta | CD34 | VGNC | VGNC:70760 |
| Canis familiaris | CD34 | VGNC | VGNC:38950 |
| Mus musculus | CD34 | MGD | MGI:88329 |
| Felis catus | CD34 | VGNC | VGNC:60613 |
| Others | CD34 | NCBI |