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Cat. No.: HY-15001A

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Stemregenin 1 hydrochloride

(Synonyms: SR1 hydrochloride)

18 Cited Publications

Customer Review

Based on 18 publication(s) in Google Scholar

Stemregenin 1 hydrochloride is a purine derivative that antagonizes aryl hydrocarbon receptor signaling in CD34+ cells. IC₅₀ The value is 127 nM. Stemregenin 1 hydrochloride can be used to expand the pluripotency of hematopoietic stem cells (HSC) in stem cell studies.

For research use only. We do not sell to patients.

CAS No.: 2319882-01-2
Formula: C₂₄H₂₄ClN₅OS
Molecular Weight:466.00

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Stemregenin 1 hydrochloride Chemical Structure

CAS No.: 2319882-01-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

CAS No. 2319882-01-2
Molecular Weight 466.00
Formula C₂₄H₂₄ClN₅OS
SMILES

CC(C)N1C2=NC(C3=CSC4=C3C=CC=C4)=NC(NCCC5=CC=C(O)C=C5)=C2N=C1.Cl
Synonyms

SR1 hydrochloride
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (18)

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Journal Impact Factor

Cell

Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation. [Abstract]

2025 Oct 16;188(21):5878-5894.e18. PMID: 40774253
Cell Stem Cell

Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer. [Abstract]

2024 Jun 6;31(6):803-817.e6. PMID: 38663406
Nat Commun

Tobacco-induced hyperglycemia promotes lung cancer progression via cancer cell-macrophage interaction through paracrine IGF2/IR/NPM1-driven PD-L1 expression. [Abstract]

2024 Jun 8;15(1):4909. PMID: 38851766

Stemregenin 1 hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Jun 8;15(1):4909. [Abstract]

Stemregenin 1 (S: SR1; 1 μM; 3 days). WB of GLUT1 and GLUT3 expression in WCL and MEM fraction.

Stemregenin 1 hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Jun 8;15(1):4909. [Abstract]

Stemregenin 1 (S: SR1; 1 μM; 3 days). Operetta high content imaging analysis of 2-NBDG fluorescent tracer uptake.
J Adv Res

Osteoblastic USP26 regulates B lymphopoiesis by endogenous tryptophan metabolites. [Abstract]

2026 Feb 11:S2090-1232(26)00141-4. PMID: 41687771
Theranostics

Activating AhR alleviates cognitive deficits of Alzheimer's disease model mice by upregulating endogenous Aβ catabolic enzyme Neprilysin. [Abstract]

2021 Aug 11;11(18):8797-8812. PMID: 34522212

Stemregenin 1 hydrochloride purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Aug 11;11(18):8797-8812. [Abstract]

N2a cells were treated with Dio (80 μM) with or without SR1 (2 μM) for 12 h. Whole cell lysates were collected and the NEP levels were determined.
Sci Adv

H3K9 dimethylation safeguards cancer cells against activation of the interferon pathway. [Abstract]

2022 Mar 18;8(11):eabf8627. PMID: 35302840
J Hazard Mater

AHR-mediated oxidative stress contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish embryos. [Abstract]

2020 Mar 5;385:121521. PMID: 31699484
Cell Chem Biol

Identification of aryl hydrocarbon receptor as a functional target that enhances astrocytic ApoE secretion. [Abstract]

2026 Jan 15;33(1):91-101.e12. PMID: 41483807
Int J Biol Macromol

Therapeutic mechanism exploration of polysaccharides from Dendrobium officinale on unilateral ureteral obstruction operation-induced renal fibrosis based on improving oxidative stress injury mediated by AhR/NOX4 pathway. [Abstract]

2023 Dec 31;253(Pt 3):126920. PMID: 37717864
Stem Cell Res Ther

DSUP modified mesenchymal stem cells exert significant radiation protective effect by enhancing the hematopoietic niche. [Abstract]

2025 May 1;16(1):216. PMID: 40312405
Chin Med

Si-Ni-San alleviates depression-like behavior via regulating the gut microbiota-tryptophan metabolism-AhR/NF-κB pathway axis. [Abstract]

2026 Apr 7;21(1):111. PMID: 41947175
Ecotoxicol Environ Saf

Hesperetin protects hippocampal neurons from the neurotoxicity of Aflatoxin B1 in mice. [Abstract]

2024 Jan 1:269:115782. PMID: 38056121
Biochem Pharmacol

Hydroquinone-selected chronic myelogenous leukemia cells are sensitive to chloroquine-induced cytotoxicity via MCL1 suppression and glycolysis inhibition. [Abstract]

2023 Dec:218:115934. PMID: 37989415
Food Funct

Fructooligosaccharides protect against OVA-induced food allergy in mice by regulating the Th17/Treg cell balance using tryptophan metabolites. [Abstract]

2021 Apr 7;12(7):3191-3205. PMID: 33735338
RSC Adv

Beneficial roles of the AhR ligand FICZ on the regenerative potentials of BMSCs and primed cartilage templates. [Abstract]

2022 Apr 13;12(18):11505-11516. PMID: 35425032

Stemregenin 1 hydrochloride purchased from MedChemExpress. Usage Cited in: RSC Adv. 2022 Apr 13;12(18):11505-11516. [Abstract]

Stemregenin 1 (SR1; 1 μM; 0-5 days).The absorbance at 450 nm of the CCK8 assay of the BMSCs. The number of viable BMSCs increased in all groups and there were no significant differences among the three groups on days 0, 1, 3 and 5 (p < 0.05).

Stemregenin 1 hydrochloride purchased from MedChemExpress. Usage Cited in: RSC Adv. 2022 Apr 13;12(18):11505-11516. [Abstract]

Stemregenin 1 (SR1; 1 μM; 0-5 days).RT-PCR demonstrated that FICZ or SR1 prevented or exacerbated LPS-induced IL-1β, 6 and TNF-α, respectively.
bioRxiv

Epigenome editing of human hematopoietic stem cells enables sustained and reversible thrombosis prevention. [Abstract]

2026 Mar 29:2026.03.27.714536. PMID: 41928991
SSRN

2025 Jul 25.
Patent

US20180263995A1.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Boitano AE, et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science. 2010 Sep 10;329(5997):1345-8 [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Stemregenin 1 hydrochloride

18 Cited Publications

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Biological Activity
- Description
Chemical Information
Publications (18)
Purity & Documentation
References

1/16
1/16

Stemregenin 1 hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Jun 8;15(1):4909. [Abstract]

Customer Validation
Stemregenin 1 (S: SR1; 1 μM; 3 days). WB of GLUT1 and GLUT3 expression in WCL and MEM fraction.
1/16

Stemregenin 1 hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Jun 8;15(1):4909. [Abstract]

Customer Validation
Stemregenin 1 (S: SR1; 1 μM; 3 days). Operetta high content imaging analysis of 2-NBDG fluorescent tracer uptake.
1/16

Stemregenin 1 hydrochloride purchased from MedChemExpress. Usage Cited in: RSC Adv. 2022 Apr 13;12(18):11505-11516. [Abstract]

Customer Validation
Stemregenin 1 (SR1; 1 μM; 0-5 days).The absorbance at 450 nm of the CCK8 assay of the BMSCs. The number of viable BMSCs increased in all groups and there were no significant differences among the three groups on days 0, 1, 3 and 5 (p < 0.05).
1/16

Stemregenin 1 hydrochloride purchased from MedChemExpress. Usage Cited in: RSC Adv. 2022 Apr 13;12(18):11505-11516. [Abstract]

Customer Validation
Stemregenin 1 (SR1; 1 μM; 0-5 days).RT-PCR demonstrated that FICZ or SR1 prevented or exacerbated LPS-induced IL-1β, 6 and TNF-α, respectively.
1/16

Stemregenin 1 hydrochloride purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Aug 11;11(18):8797-8812. [Abstract]

Customer Validation
N2a cells were treated with Dio (80 μM) with or without SR1 (2 μM) for 12 h. Whole cell lysates were collected and the NEP levels were determined.

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Stemregenin 1 hydrochloride

Publications Citing Use of MedChemExpress (MCE) Stemregenin 1 hydrochloride

Biological Activity

Chemical Information

Publications (18)

Purity & Documentation

References

Calculators

Help & FAQs

Stemregenin 1 hydrochloride Related Classifications

HY-15001A Related Classifications