BAY-364
BAY-364 (BAY-299N) is an inhibitor of the second bromine domain in TAF1. BAY-364 inhibits the TAF1 of Kasumi-1 cells, CD34+ cells and K562 cells with IC50 values of 1.0 µM, 10.4 µM and 10.0 µM respectively.
For research use only. We do not sell to patients.
- CAS No.: 2097610-30-3
- Formula: C23H19N3O4
- Molecular Weight:401.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
BAY-364 (0.1-100 µM; 3 d) inhibits the growth of Kasumi-1 cells, CD34+ cells and K562 cells[1].
BAY-364 (72 h) decreases the expression of ID1, MYC and TAF1 but insignificantly affect the expression of AE in the Kasumi-1 cells[1].
BAY-364 (10 µM; 2 d) reduces colony formation in AE9a+ cells[1].
BAY-364 (2 µM; 48 h and 72 h) has insignificant effect on the cell cycle of K562 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:K562 cells.
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Concentration:2 µM.
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Incubation Time:48 h and 72 h.
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Result:Had insignificant effect on the cell cycle.
Chemical Information
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CAS No. 2097610-30-3
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Molecular Weight 401.41
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Formula C23H19N3O4
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SMILES
O=C1NC2=CC(N3C(C4=CC=CC5=C4C(C3=O)=CC=C5CCCO)=O)=CC=C2N1C
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Synonyms
BAY-299N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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