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Cat. No.: HY-150239

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BAY-364

Name: BAY-364
Brand: MedChemExpress
SKU: HY-150239
Availability: PreOrder

(Synonyms: BAY-299N)

BAY-364 (BAY-299N) is an inhibitor of the second bromine domain in TAF1. BAY-364 inhibits the TAF1 of Kasumi-1 cells, CD34⁺ cells and K562 cells with IC₅₀ values of 1.0 µM, 10.4 µM and 10.0 µM respectively.

For research use only. We do not sell to patients.

CAS No.: 2097610-30-3
Formula: C₂₃H₁₉N₃O₄
Molecular Weight:401.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

BAY-364 Chemical Structure

CAS No.: 2097610-30-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

BAY-364 (0.1-100 µM; 3 d) inhibits the growth of Kasumi-1 cells, CD34⁺ cells and K562 cells^[1].
BAY-364 (72 h) decreases the expression of ID1, MYC and TAF1 but insignificantly affect the expression of AE in the Kasumi-1 cells^[1].
BAY-364 (10 µM; 2 d) reduces colony formation in AE9a⁺ cells^[1].
BAY-364 (2 µM; 48 h and 72 h) has insignificant effect on the cell cycle of K562 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Cell Cycle Analysis^[2]

View Protocol

Cell Line:

K562 cells.
Concentration:

2 µM.
Incubation Time:

48 h and 72 h.
Result:

Had insignificant effect on the cell cycle.

Chemical Information

CAS No. 2097610-30-3
Molecular Weight 401.41
Formula C₂₃H₁₉N₃O₄
SMILES

O=C1NC2=CC(N3C(C4=CC=CC5=C4C(C3=O)=CC=C5CCCO)=O)=CC=C2N1C
Synonyms

BAY-299N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xu Y, et al. TAF1 plays a critical role in AML1-ETO driven leukemogenesis. Nat Commun. 2019 Oct 29;10(1):4925. [Content Brief]

[2]. Garcia-Carpizo V, et al. Therapeutic potential of TAF1 bromodomains for cancer treatment[J]. bioRxiv, 2018: 394254.

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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