Glucocerebrosidase-IN-1 hydrochloride

製品番号: HY-147976A 純度: 99.16%: Data Sheet SDS COA 取扱説明書
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Glucocerebrosidase-IN-1 (compound 11a) hydrochloride is a potent and selective GCase (glucocerebrosidase) inhibitor, with an IC₅₀ of 29.3 μM and a K_i of 18.5 μM. Glucocerebrosidase-IN-1 hydrochloride can be used for the research of Gaucher disease (GD) and Parkinson’s disease (PD).

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Glucocerebrosidase-IN-1 hydrochloride 構造式

CAS 番号 : 2279945-77-4

容量	価格（税別）	在庫状況	数量
1 mg	$459	在庫あり	Estimated Time of Arrival: December 31
5 mg	$1148	在庫あり	Estimated Time of Arrival: December 31
10 mg	$1837	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Other Forms of Glucocerebrosidase-IN-1 hydrochloride:

Glucocerebrosidase-IN-1 在庫あり

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製品説明

分子量

281.82

分子式

C₁₃H₂₈ClNO₃

CAS 番号

2279945-77-4

Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1[C@@H](CCCCCCCC)NC[C@@H](O)[C@H]1O.[H]Cl

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 12.5 mg/mL (44.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5484 mL	17.7418 mL	35.4836 mL
5 mM	0.7097 mL	3.5484 mL	7.0967 mL
10 mM	0.3548 mL	1.7742 mL	3.5484 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

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体積 _（開始）

濃度 _（終了）

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.16%

Select Batch:

データシート (268 KB) SDS (251 KB)

COA (244 KB) HNMR (256 KB) LCMS (321 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Clemente F, et al. Glucocerebrosidase (GCase) activity modulation by 2-alkyl trihydroxypiperidines: Inhibition and pharmacological chaperoning. Bioorg Chem. 2020 May;98:103740. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5484 mL	17.7418 mL	35.4836 mL	88.7091 mL
	5 mM	0.7097 mL	3.5484 mL	7.0967 mL	17.7418 mL
	10 mM	0.3548 mL	1.7742 mL	3.5484 mL	8.8709 mL
	15 mM	0.2366 mL	1.1828 mL	2.3656 mL	5.9139 mL
	20 mM	0.1774 mL	0.8871 mL	1.7742 mL	4.4355 mL
	25 mM	0.1419 mL	0.7097 mL	1.4193 mL	3.5484 mL
	30 mM	0.1183 mL	0.5914 mL	1.1828 mL	2.9570 mL
	40 mM	0.0887 mL	0.4435 mL	0.8871 mL	2.2177 mL