Glucocerebrosidase-IN-1 hydrochloride

Cat. No.: HY-147976A Purity: 99.16%: Data Sheet
COA

SDS
Handling Instructions
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Glucocerebrosidase-IN-1 (compound 11a) hydrochloride is a potent and selective GCase (glucocerebrosidase) inhibitor, with an IC₅₀ of 29.3 μM and a K_i of 18.5 μM. Glucocerebrosidase-IN-1 hydrochloride can be used for the research of Gaucher disease (GD) and Parkinson’s disease (PD).

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Glucocerebrosidase-IN-1 hydrochloride 화학구조

CAS No. : 2279945-77-4

사이즈	재고	수량
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of Glucocerebrosidase-IN-1 hydrochloride:

Glucocerebrosidase-IN-1 In-stock

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

분자량

281.82

화학식

C₁₃H₂₈ClNO₃

CAS No.

2279945-77-4

Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1[C@@H](CCCCCCCC)NC[C@@H](O)[C@H]1O.[H]Cl

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 12.5 mg/mL (44.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5484 mL	17.7418 mL	35.4836 mL
5 mM	0.7097 mL	3.5484 mL	7.0967 mL
10 mM	0.3548 mL	1.7742 mL	3.5484 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

순도&문서

Purity: 99.16%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (244 KB) HNMR (256 KB) LCMS (321 KB)

Handling Instructions (2659 KB)

References

[1]. Clemente F, et al. Glucocerebrosidase (GCase) activity modulation by 2-alkyl trihydroxypiperidines: Inhibition and pharmacological chaperoning. Bioorg Chem. 2020 May;98:103740. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5484 mL	17.7418 mL	35.4836 mL	88.7091 mL
	5 mM	0.7097 mL	3.5484 mL	7.0967 mL	17.7418 mL
	10 mM	0.3548 mL	1.7742 mL	3.5484 mL	8.8709 mL
	15 mM	0.2366 mL	1.1828 mL	2.3656 mL	5.9139 mL
	20 mM	0.1774 mL	0.8871 mL	1.7742 mL	4.4355 mL
	25 mM	0.1419 mL	0.7097 mL	1.4193 mL	3.5484 mL
	30 mM	0.1183 mL	0.5914 mL	1.1828 mL	2.9570 mL
	40 mM	0.0887 mL	0.4435 mL	0.8871 mL	2.2177 mL