2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. GNUV201

GNUV201 is a PD-1 inhibitor with cross-reactivity in humans, mice and monkeys, which effectively blocks the PD-1/PD-L1 interaction. GNUV201 activates T cells and restores their anti-tumor activity, effectively inducing tumor regression. GNUV201 can be used in the research of related diseases such as colorectal cancer, melanoma, pancreatic cancer and colon cancer.

For research use only. We do not sell to patients.

GNUV201

GNUV201 Chemical Structure

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GNUV201 Related Antibodies

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Description

GNUV201 is a PD-1 inhibitor with cross-reactivity in humans, mice and monkeys, which effectively blocks the PD-1/PD-L1 interaction. GNUV201 activates T cells and restores their anti-tumor activity, effectively inducing tumor regression. GNUV201 can be used in the research of related diseases such as colorectal cancer, melanoma, pancreatic cancer and colon cancer[1][2].

Species Reactivity

Human
In Vitro

GNUV201 and its chimeric precursors bind to CHO cells expressing human PD-1 (EC50=117 pM) and CHO cells expressing mouse PD-1 (EC50=203 pM) with comparable affinities[1].
GNUV201 (15 min, 1 h) blocks the human PD-1/PD-L1 interaction in flow cytometry-based assays with an IC50 of 9.9 nM; it also blocks the murine PD-1/PD-L1 interaction with an IC50 of 6.7 nM[1].
GNUV201 blocks the interaction between human PD-1/PD-L1 in luciferase reporter gene assays, with an IC50 value of 6.3 nM[1].
GNUV201 cross-reacts with mouse PD-1 (EC50=32 pM) and human PD-1 (EC50=28 pM). It has a slower dissociation rate than Keytruda, and exhibits significantly higher binding affinity under acidic pH conditions (Kd=0.9 nM; pH=6.0)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GNUV201 Related Antibodies
In Vivo

GNUV201 (1-10 mg/kg; i.p.; twice weekly; 2-3 weeks) dose-dependently inhibits MC38 colorectal cancer growth in C57BL/6 mice, achieving 73% TGI at 10 mg/kg and improving survival in ~20% of treated mice[1].
GNUV201 inhibits tumor growth in the MC38/hPD-1 knock-in mouse colon cancer model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (female, 7 weeks old, subcutaneous implantation of 1×106 MC38 murine colorectal cancer cells)[1]
Dosage: 1 mg/kg; 3 mg/kg; 10 mg/kg
Administration: i.p.; twice weekly; 2-3 weeks
Result: Exhibited dose-dependent tumor growth inhibition with 24% TGI at 1 mg/kg, 59% TGI at 3 mg/kg, and 73% TGI on day 15 post-treatment.
Achieved statistically significant improvement in overall survival, with ~20% of mice surviving without tumor growth at 10 mg/kg.
Gene ID

5133  [NCBI]

Accession
Target

PDCD1/PD-1/CD279
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GNUV201 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GNUV201GNUV 201GNUV-201PD-1/PD-L1PD-1/Programmed death-ligand 1colorectal cancerCD3+ T cellspancreatic cancerT cellsMC38melanomaPD-L1colon cancerCHO cellsPD-1Inhibitorinhibitorinhibit

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