HATU

Cat. No.: HY-Y1703 Purity: 99.94%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

HATU is a third-generation uronium salt peptide coupling reagent. HATU increases the rate of peptide coupling reactions, activates amino acids, promotes peptide bond formation in both solution-phase and solid-phase synthesis, and also facilitates peptide assembly, fragment coupling, and linear peptide cyclization. HATU can promote the N-acylation of chitosan to generate amide-linked cationic derivatives with a controllable degree of substitution. HATU is commonly used in amine acylation reactions.

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HATU 화학구조

CAS No. : 148893-10-1

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
25 g	해외재고보유	Estimated Time of Arrival: December 31
50 g	해외재고보유	Estimated Time of Arrival: December 31
100 g	해외재고보유	Estimated Time of Arrival: December 31
500 g	해외재고보유	Estimated Time of Arrival: December 31
> 100 g	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vitro

HATU (0.3-3 eq; 2 h) mediates efficient, controlled N-acylation of chitosan in DMSO, enabling targeted DS values from ~10% to ~86% for TAC and successful one-pot mixed N-acylation with aromatic carboxylic acids, with reaction efficiency optimized via Design of Experiments^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

380.23

화학식

C₁₀H₁₅F₆N₆OP

CAS No.

148893-10-1

Appearance

Solid

Color

White to off-white

SMILES

F[P-](F)(F)(F)(F)F.C/[N+](C)=C(N(C)C)/ON1C2=NC=CC=C2N=N1

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 200 mg/mL (526.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6300 mL	13.1499 mL	26.2999 mL
5 mM	0.5260 mL	2.6300 mL	5.2600 mL
10 mM	0.2630 mL	1.3150 mL	2.6300 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.98%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (249 KB) HNMR (129 KB) RP-HPLC (288 KB)

Handling Instructions (2659 KB)

References

[1]. Louis A. Carpino. 1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additive. J. Am. Chem. Soc. 1993, 115, 10, 4397-4398.

[2]. Luca Protti, et al. HATU Coupling for Fast, Efficient, and Selective N-acylation of chitosan: DoE-optimized synthesis of cationic antibacterial derivatives. Carbohydrate Polymers Volume 380, 15 May 2026, 125012.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6300 mL	13.1499 mL	26.2999 mL	65.7497 mL
	5 mM	0.5260 mL	2.6300 mL	5.2600 mL	13.1499 mL
	10 mM	0.2630 mL	1.3150 mL	2.6300 mL	6.5750 mL
	15 mM	0.1753 mL	0.8767 mL	1.7533 mL	4.3833 mL
	20 mM	0.1315 mL	0.6575 mL	1.3150 mL	3.2875 mL
	25 mM	0.1052 mL	0.5260 mL	1.0520 mL	2.6300 mL
	30 mM	0.0877 mL	0.4383 mL	0.8767 mL	2.1917 mL
	40 mM	0.0657 mL	0.3287 mL	0.6575 mL	1.6437 mL
	50 mM	0.0526 mL	0.2630 mL	0.5260 mL	1.3150 mL
	60 mM	0.0438 mL	0.2192 mL	0.4383 mL	1.0958 mL
	80 mM	0.0329 mL	0.1644 mL	0.3287 mL	0.8219 mL
	100 mM	0.0263 mL	0.1315 mL	0.2630 mL	0.6575 mL

HATU Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HATU148893-10-1Biochemical Assay ReagentschitosanStaphylococcus aureusracemizationpeptide bond formationsolid-phase synthesispeptide couplinganaphylaxisamino acidschiral integrityhuman proteinsInhibitorinhibitorinhibit

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HATU

HATU Related Antibodies

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Biological Activity

순도&문서

References

고객리뷰

HATU Related Antibodies

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